Evidence map›Paper›PMID 36241239›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2022

[A 10-year retrospective analysis of spectrums and treatment options of orthostatic intolerance and sitting intolerance in children].

Y X Cui, J B DU, Q Y Zhang, Y Liao, P Liu, Y L Wang, J G Qi, H Yan, W R Xu, X Q Liu and 5 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Y X CuiDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
J B DUDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Q Y ZhangDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Y LiaoDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
P LiuDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Y L WangDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
J G QiDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
H YanDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
W R XuDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
X Q LiuDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Y SunDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
C F SunDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
C Y ZhangDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Y H ChenDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
H F JinDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Peking University First Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the disease spectrums underlying orthostatic intolerance (OI) and sitting intolerance (SI) in Chinese children, and to understand the clinical empirical treatment options.

methodsThe medical records including history, physical examination, laboratory examination, and imagological examination of children were retrospectively studied in Peking University First Hospital from 2012 to 2021. All the children who met the diagnostic criteria of OI and SI were enrolled in the study. The disease spectrums underlying OI and SI and treatment options during the last 10 years were analyzed.

resultsA total of 2 110 cases of OI and SI patients were collected in the last 10 years, including 943 males (44.69%) and 1 167 females (55.31%) aged 4－18 years, with an average of (11.34±2.84) years. The overall case number was in an increasing trend over the year. In the OI spectrum, postural tachycardia syndrome (POTS) accounted for 826 cases (39.15%), followed by vasovagal syncope (VVS) (634 cases, 30.05%). The highest proportion of SI spectrum was sitting tachycardia (STS) (8 cases, 0.38%), followed by sitting hypertension (SHT) (2 cases, 0.09%). The most common comorbidity of OI and SI was POTS coexisting with STS (36 cases, 1.71%). The highest proportion of treatment options was autonomic nerve function exercise (757 cases, 35.88%), followed by oral rehydration salts (ORS) (687 cases, 32.56%), metoprolol (307 cases, 14.55%), midodrine (142 cases, 6.73%), ORS plus metoprolol (138 cases, 6.54%), and ORS plus midodrine (79 cases, 3.74%). The patients with POTS coexisting with VVS were more likely to receive pharmacological intervention than the patients with POTS and the patients with VVS (41.95%

conclusionPOTS and VVS in children are the main underlying diseases of OI, while SI is a new disease discovered recently. The number of children with OI and SI showed an increasing trend. The main treatment methods are autonomic nerve function exercise and ORS. Children with VVS coexisting with POTS were more likely to take pharmacological treatments than those with VVS or POTS only.

Indexed as

MidodrineOrthostatic IntolerancePostural Orthostatic Tachycardia SyndromeSyncope, VasovagalChildElectrolytesFemaleHumansMaleMetoprololRetrospective StudiesSaltsSitting PositionTilt-Table TestElectrolytesMetoprololMidodrineSaltsChildrenDisease spectrumOrthostatic intoleranceSitting intolerance

Identifiers

PMID36241239
PMCPMC9568388
OpenAlexW4306316454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.