Evidence map›Paper›PMID 36241232›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2022

[Naringenin inhibits thoracic aortic aneurysm formation in mice with Marfan syndrome].

Z Q Li, B Yu, Z Y Cai, Y B Wang, X Zhang, B Zhou, X H Fang, F Yu, Y Fu, J P Sun and 2 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Z Q LiDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
B YuDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Z Y CaiDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Y B WangDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
X ZhangDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
B ZhouDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
X H FangInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
F YuDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Y FuDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
J P SunDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
W LiDepartment of Vascular Surgery, Peking University People's Hospital, Beijing 100044, China.
W KongDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China.
Peking University · CNChina-Japan Friendship Hospital · CNInstitute of Chemistry · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify whether naringenin plays a protective role during thoracic aneurysm formation in Marfan syndrome.

methodsTo validate the effect of naringenin,

resultsSix-week-old

conclusionOur study showed that naringenin has a protective effect on thoracic aortic aneurysm formation in Marfan syndrome by suppressing both AT1 and TGF-β signaling.

Indexed as

Aortic Aneurysm, ThoracicMarfan SyndromeAngiotensin IIAnimalsbeta-ArrestinsCalciumDisease Models, AnimalElastinFibrillin-1FlavanonesMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Inbred C57BLProtein Kinase CReceptor, Angiotensin, Type 1Angiotensin IIbeta-ArrestinsCalciumElastinFibrillin-1FlavanonesMatrix Metalloproteinase 2Matrix Metalloproteinase 9naringeninProtein Kinase CReceptor, Angiotensin, Type 1Transforming Growth Factor betaTransforming Growth FactorsAngiotensin Ⅱ type 1 receptor (AT1)Marfan syndromeNaringeninThoracic aortic aneurysmTransforming growth factor-β (TGF-β)

Identifiers

PMID36241232
PMCPMC9568379
OpenAlexW4306316638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.