ArticleJournal of the American Chemical Society2022
Chemical Kinetics and Mass Action in Coexisting Phases.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 0 citations in OpenAlex.
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- Local environment in biomolecular condensates modulates enzymatic activity across length scales.Nature communications · 2024Article
- Compartmental exchange regulates steady states and stochastic switching of a phosphorylation network.Biophysical journal · 2024Article
- Nonequilibrium Wet-Dry Cycling Acts as a Catalyst for Chemical Reactions.The journal of physical chemistry. B · 2024Article
- Dynamical control enables the formation of demixed biomolecular condensates.Nature communications · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of chemical reactions are determined by the law of mass action, which has been successfully applied to homogeneous, dilute mixtures. At nondilute conditions, interactions among the components can give rise to coexisting phases, which can significantly alter the kinetics of chemical reactions. Here, we derive a theory for chemical reactions in coexisting phases at phase equilibrium. We show that phase equilibrium couples the rates of chemical reactions of components with their diffusive exchanges between the phases. Strikingly, the chemical relaxation kinetics can be represented as a flow along the phase equilibrium line in the phase diagram. A key finding of our theory is that differences in reaction rates between coexisting phases stem solely from phase-dependent reaction rate coefficients. Our theory is key to interpreting how concentration levels of reactive components in condensed phases control chemical reaction rates in synthetic and biological systems.
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