ArticleThe Journal of hospital infection2023
Detailed analysis of in-hospital transmission of SARS-CoV-2 using whole genome sequencing.
Article in The Journal of hospital infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Variability in the Population Diffusion Patterns of SARS-CoV-2 by Exposure Setting and Its Roles in Driving Epidemic Dynamics.Influenza and other respiratory viruses · 2025Article
- A longitudinal qualitative exploration of victorian healthcare workers' and organisations' evolving views and experiences during COVID-19.BMC health services research · 2024Article
- Robust epidemiological investigations in hospital-based COVID-19 outbreaks cannot be overlooked-even in the era of whole-genome sequencing.The Journal of hospital infection · 2023Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundHospital transmission of SARS-CoV-2 has proved difficult to control, with healthcare-associated infections troublesome throughout.
aimTo understand factors contributing to hospital transmission of infections, which is necessary for containing spread.
methodsAn outbreak of 56 staff and patient cases of COVID-19 over a 31-day period in a tertiary referral unit is presented, with at least a further 29 cases identified outside of the unit and the hospital by whole genome sequencing (WGS).
findingsTransmission is documented from staff to staff, staff to patients, and patients to staff, showing disruption of a tertiary referral service, despite implementation of nationally recommended control measures, superior ventilation, and use of personal protective equipment. There was extensive spread from the index case, despite this patient spending only 10 h bed bound on the ward in strict cubicle isolation and with an initial single target low level (C
conclusionThis investigation highlights how effectively and rapidly SARS-CoV-2 can spread in certain circumstances. It raises questions about infection control measures in place at the time and calls into question the premise that transmissibility can be reliably detected by using lower sensitivity rapid antigen lateral flow tests. We also highlight the value of early intervention in reducing impact as well as the value of WGS in understanding outbreaks.
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