ArticlePreventive medicine2022
Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001-2017.
Article in Preventive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Development of a theory-based provider-focused training to improve HPV vaccine recommendations for young adults.Human vaccines & immunotherapeutics · 2026Article
- Racial disparities in time to treatment initiation and survival outcomes in patients with vulvar cancer: a national cancer database analysis.International journal of clinical oncology · 2026Observational
- Treatment patterns and outcomes in perineal primary vulvar cancer-a population-based Swedish cohort study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Role of primary chemoradiotherapy in the management of advanced stage vulvar cancer : Experience of a large cancer center.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Consideration for HPV vaccination recommendations in patients with vulvar dysplasia and malignancy following resection: A retrospective study investigating rural-urban vaccination practices in patients served by an academic medical center in the heartland.Gynecologic oncology reports · 2026Article
- The impact of absent vulvar cancer screening guidelines on outcomes of vulvar squamous cell carcinoma: a national cancer database study.Cancer causes & control : CCC · 2026Article
- Article
- Combinatorial Effects of Plasma-Treated Solution and Plasma-Treated Hydrogel with Cisplatin in Vulvar Cancer Cells.Oncology research · 2026Article
- Impact of Surgical Margin Distance on Oncologic Outcomes in Vulvar Squamous Cell Carcinoma.Journal of clinical medicine · 2025Article
- A novel tumor budding and cell nest size-based grading system outperforms conventional methods in vulvar squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2025Article
- Symptom Experience After Surgical Treatment for Vulvar Cancer-A Scoping Review.Scandinavian journal of caring sciences · 2025Article
- Controversies in vulvar cancer: revisiting the margin of error.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025Review
- Disparities and trends of the incidence and mortality of female-specific cancers in the United States.PloS one · 2025Article
- Intersecting Pathologies: Vulvar Cancer Complicated by a Fusobacterium necrophorum Infection.Cureus · 2024Article
- Incidence Trends of Vulvar Cancer in the United States: A 20-Year Population-Based Study.Cancer reports (Hoboken, N.J.) · 2024Article
- Sexually transmitted infections and the HPV-related burden: evolution of Italian epidemiology and policy.Frontiers in public health · 2024Article
- Article
- Human Papillomavirus Detection in Scrotal Squamous Cell Carcinoma: Case Series from a Population-Based Cancer Registry.Journal of registry management · 2023Article
- Characterization of Human Papillomavirus 16 from Kinshasa (Democratic Republic of the Congo)-Implications for Pathogenicity and Vaccine Effectiveness.Microorganisms · 2022Article
- Comprehensive management of vulvovaginal cancers.CA: a cancer journal for cliniciansReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Vulvar cancer incidence has been rising in recent years, possibly due to increasing exposure to human papillomavirus (HPV). We assessed incidence rates of HPV-associated and non-HPV-associated vulvar cancers diagnosed from 2001 to 2017 in the United States (US). Using population-based cancer registry data covering 99% of the US population, incidence rates were calculated and stratified by age, race/ethnicity, stage, geographic region, and histology. The average annual percent change in incidence per year were calculated using joinpoint regression. From 2001 to 2017, the incidence of HPV-associated vulvar cancers increased by 1.2% per year, most notably among women who were aged 50-59 years (2.6%), 60-69 years (2.4%), and ≥ 70 years (0.9%); of White (1.5%) and Black (1.1%) race; diagnosed at an early (1.3%) and late (1.8%) stage; and living in the Midwest (1.9%), Northeast (1.4%), and South (1.2%). Incidence increased each year for HPV-associated histologic subtypes including keratinizing (4.7%), non-keratinizing (6.0%), and basaloid (3.1%) squamous cell carcinomas (SCCs), while decreases were found in warty (2.7%) and microinvasive (5.5%) SCCs. HPV-associated vulvar cancer incidence increased overall and among women aged over 50 years while remaining stable among women younger than 50 years. The overall incidence for non-HPV-associated cancers was stable. Continued surveillance of HPV-associated cancers will allow us to monitor future trends as HPV vaccination coverage increases in the US.
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Registered trials
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