Evidence map›Paper›PMID 36240903›Full record

Trial reportContraception2023

Switching and discontinuation of participant-masked randomization to a copper or levonorgestrel intrauterine device when presenting for emergency contraception.

Jessica Kaplan, David K Turok, Alexandra Gero, Jennifer E Kaiser, Rebecca G Simmons, Kathryn E Fay

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contraception, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jessica KaplanSouthwest Medical Group Women's & Family Health, Cortez, CO, United States.
David K TurokDepartment of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Alexandra GeroDepartment of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Jennifer E KaiserDepartment of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Rebecca G SimmonsDepartment of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Kathryn E FayDepartment of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA, United States. Electronic address: kefay@bwh.harvard.edu.
University of Utah · USHarvard University · USSouthwest Women's Oncology · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
University of Utah Center for Clinical and Translational Science-UL1UL1TR000105 · NCATS · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2012 to 2013
$5.1M
RCT Assessing Pregnancy with Intrauterine Devices for Emergency ContraceptionR01HD083340 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI David Turok · 2015 to 2026
$3.6M
Transdisciplinary Harvard WRHR Career Development for Gynecologists and ObstetriciansK12HD103096 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NOUR, NAWAL M. · 2020 to 2024
$1.5M
Midcareer Investigator Award in Patient-Oriented Research K24K24HD087436 · NICHD · UNIVERSITY OF UTAH · PI TUROK, DAVID · 2017 to 2021
$942k
NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR002538NCRR NIH HHS UL1 RR025764NICHD NIH HHS K12 HD103096NICHD NIH HHS K24 HD087436NICHD NIH HHS R01 HD083340
6 · The paper itself

Abstract

objectivesExamine intrauterine device (IUD) switching or discontinuation up to 6 months after participant-masked randomization to different IUDs. STUDY

designParticipants were randomized 1:1 to the copper T380A or levonorgestrel 52 mg IUD for emergency contraception and informed they could switch IUD type without cost at any time.

resultsOf the 327 subjects allocated to the levonorgestrel IUD, 7 (2.1%) switched their IUD type by 6 months versus 18 (5.5%) of the 328 copper IUD users (RR: 0.4 [95% CI: 0.2, 0.9], p = 0.03). Six-month IUD discontinuation occurred in 34 (10.4%) levonorgestrel and 35 (10.7%) copper IUD users.

conclusionIndividuals randomly assigned to IUD type at presentation for emergency contraception continue their assigned IUDs at high rates over 6 months. IMPLICATIONS: While many recruited individuals declined enrollment, those who accepted randomization had high continuation rates; the high continuation and low cross-over supports using IUD randomization as a tool for future investigation. Participants' similar rates of and reasons for switching and discontinuation by IUD type over the study period may impact clinical counseling.

Indexed as

Contraception, PostcoitalIntrauterine Devices, CopperIntrauterine Devices, MedicatedFemaleHumansLevonorgestrelRandom AllocationLevonorgestrelContraceptionIntrauterine deviceLong acting reversible contraceptionRandomizationRandomized controlled trial

Identifiers

PMID36240903
PMCPMC9839545
OpenAlexW4304688748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.