Evidence map›Paper›PMID 36240881›Full record

ArticleExperimental neurology2023

A single closed head injury in male adult mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes.

David F Havlicek, Rachel Furhang, Elena Nikulina, Bayle Smith-Salzberg, Siobhán Lawless, Sasha A Severin, Sevara Mallaboeva, Fizza Nayab, Alan C Seifert, John F Crary and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

David F HavlicekSchool of Graduate Studies, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Rachel FurhangSchool of Graduate Studies, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Elena NikulinaDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Bayle Smith-SalzbergDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Siobhán LawlessSchool of Graduate Studies, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Sasha A SeverinDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Sevara MallaboevaDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Fizza NayabDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America.
Alan C SeifertDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
John F CraryDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Peter J BergoldDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States of America. Electronic address: peter.bergold@downstate.edu.
SUNY Downstate Health Sciences University · USState University of New York · USIcahn School of Medicine at Mount Sinai · US

Funding

Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
Minocycline Plus N-Acetylcysteine Improves Brain Structure and Function After Experimental Brain Injury with Clinically Useful Time WindowsR01NS108190 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI BERGOLD, PETER J, SACKTOR, TODD C · 2019 to 2023
$2.6M
Remyelination after traumatic brain injuryR01NS076693 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI BERGOLD, PETER J · 2013 to 2015
$839k
NIMH NIH HHS R01 MH115304NINDS NIH HHS R01 NS076693NINDS NIH HHS R01 NS108190
6 · The paper itself

Abstract

Traumatic brain injury (TBI) acutely damages the brain; this injury can evolve into chronic neurodegeneration. While much is known about the chronic effects arising from multiple mild TBIs, far less is known about the long-term effects of a single moderate to severe TBI. We found that a single moderate closed head injury to mice induces diffuse axonal injury within 1-day post-injury (DPI). At 14 DPI, injured animals have atrophy of ipsilesional cortex, thalamus, and corpus callosum, with bilateral atrophy of the dorsal fornix. Atrophy of the ipsilesional corpus callosum is accompanied by decreased fractional anisotropy and increased mean and radial diffusivity that remains unchanged between 14 and 180 DPI. Injured animals show an increased density of phospho-tau immunoreactive (pTau

Indexed as

Brain Injuries, TraumaticHead Injuries, ClosedWhite MatterAnimalsAtrophyCorpus CallosumDiffusion Tensor ImagingMaleMiceOligodendrogliaDT-MRIIpsilesional vs. contralesionalModerate traumatic brain injuryProximity to impact siteT2 MRIThioflavin S

Identifiers

PMID36240881
PMCPMC12587492
OpenAlexW4304812145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.