Evidence map›Paper›PMID 36240834›Full record

ReviewThe lancet. HIV2022

Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel.

Maurine D Miner, Mark Hatherill, Vidya Mave, Glenda E Gray, Sharon Nachman, Sarah W Read, Richard G White, Anneke Hesseling, Frank Cobelens, Sheral Patel and 22 more

Erratum issuedOpen access · greenAbstract readReviewConsensus Statement
In one paragraph

Review in The lancet. HIV, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Drug resistance mechanisms inFrontiers in pharmacology · 2026
    Review
  2. Article
  3. Review
  4. Challenges in developing new tuberculosis vaccines.Memorias do Instituto Oswaldo Cruz · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 7 countries.

Maurine D MinerFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mark HatherillSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Vidya MaveJohns Hopkins India, Byramjee-Jeejeebhoy Government Medical College Clinical Research Site, Pune, India.
Glenda E GraySouth African Medical Research Council, Cape Town, South Africa.
Sharon NachmanDepartment of Pediatrics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Sarah W ReadDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Richard G WhiteDepartment of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Anneke HesselingDesmond Tutu Tuberculosis Centre, Stellenbosch University, Stellenbosch, South Africa.
Frank CobelensDepartment of Global Health, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Sheral PatelUS Food and Drug Administration, Silver Spring, MD, USA.
Mike FrickTreatment Action Group, New York, NY, USA.
Theodore BaileyGreater Baltimore Medical Center, Baltimore, MD, USA.
Robert SederVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Joanne FlynnMicrobiology and Molecular Genetics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Jyothi RengarajanEmory School of Medicine, Emory University, Atlanta, GA, USA.
Deepak KaushalTexas Biomedical Research Institute, San Antonio, TX, USA.
Willem HanekomAfrica Health Research Institute, Durban, KwaZulu-Natal, South Africa.
Alexander C SchmidtGates Medical Research Institute, Boston, MA, USA.
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Elisa NemesSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Erica Andersen-NissenFred Hutchinson Cancer Research Center, Seattle, WA, USA; Cape Town HIV Vaccine Trials Network (HVTN) Immunology Laboratory, Cape Town, South Africa.
Alan LandayRush Medical Center, Chicago, IL, USA.
Susan E DormanDepartment of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Grace AldrovandiDepartment of Pediatrics, University of California, Los Angeles, CA, USA.
Lisa M CranmerEmory School of Medicine, Emory University, Atlanta, GA, USA.
Cheryl L DayEmory School of Medicine, Emory University, Atlanta, GA, USA.
Alberto L Garcia-BasteiroISGlobal, Hospital Clínic Universitat de Barcelona, Barcelona, Spain; Centro de investigação de Saúde de Manhiça, Maputo, Mozambique.
Andrew Fiore-GartlandFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Robin MoggTakeda Pharmaceutical Company, Cambridge, MA, USA.
James G KublinFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Amita GuptaDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gavin ChurchyardThe Aurum Institute, Johannesburg, South Africa; School of Public Health, University of Witwatersrand, Johannesburg, South Africa; Department of Medicine, Vanderbilt University, Nashville, TN, USA. Electronic address: gchurchyard@auruminstitute.org.
Fred Hutch Cancer Center · USEmory University · USSouth African Tuberculosis Vaccine Initiative · ZAAfrica Health Research Institute · ZAAmsterdam University Medical Centers · NLAurum Institute · ZABarcelona Institute for Global Health · ESGates (United States) · USGovernment Medical College · INGreater Baltimore Medical Center · USJohns Hopkins University · USLondon School of Hygiene & Tropical Medicine · GBMedical University of South Carolina · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USRush University Medical Center · USSouth African Medical Research Council · ZAStellenbosch University · ZAStony Brook University · USTakeda (United States) · US

Funding

LOC: HIV Vaccine Trials NetworkUM1AI068614 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Dan H. Barouch, Lawrence Corey · 2011 to 2026
$1175.6M
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
The Johns Hopkins Baltimore-Washington-India Clinical Trials Unit (BWI CTU)UM1AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Charles W. Flexner, Amita Gupta · 2012 to 2026
$34.1M
Aurum Clinical Trials UnitUM1AI154463 · NIAID · AURUM INSTITUTE NPC · PI Gavin John Churchyard · 2021 to 2026
$8.1M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Neel Rajnikant Gandhi, Jyothi Rengarajan · 2022 to 2026
$5.8M
The role of antibodies in infant TB preventionK23AI143479 · NIAID · EMORY UNIVERSITY · PI CRANMER, LISA M · 2019 to 2023
$950k
NIAID NIH HHS K23 AI143479NIAID NIH HHS P30 AI168386NIAID NIH HHS UM1 AI068614NIAID NIH HHS UM1 AI068618NIAID NIH HHS UM1 AI068635NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069465NIAID NIH HHS UM1 AI154463NIH HHS P51 OD011133
6 · The paper itself

Abstract

New tuberculosis vaccine candidates that are in the development pipeline need to be studied in people with HIV, who are at high risk of acquiring Mycobacterium tuberculosis infection and tuberculosis disease and tend to develop less robust vaccine-induced immune responses. To address the gaps in developing tuberculosis vaccines for people with HIV, a series of symposia was held that posed six framing questions to a panel of international experts: What is the use case or rationale for developing tuberculosis vaccines? What is the landscape of tuberculosis vaccines? Which vaccine candidates should be prioritised? What are the tuberculosis vaccine trial design considerations? What is the role of immunological correlates of protection? What are the gaps in preclinical models for studying tuberculosis vaccines? The international expert panel formulated consensus statements to each of the framing questions, with the intention of informing tuberculosis vaccine development and the prioritisation of clinical trials for inclusion of people with HIV.

Indexed as

HIV InfectionsMycobacterium tuberculosisTuberculosisTuberculosis VaccinesHumansTuberculosis Vaccines

Identifiers

PMID36240834
PMCPMC9667733
OpenAlexW4304471686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.