Evidence map›Paper›PMID 36240831›Full record

ArticleThe Lancet. Global health2022

Evaluating the effect of measles and rubella mass vaccination campaigns on seroprevalence in India: a before-and-after cross-sectional household serosurvey in four districts, 2018-2020.

Manoj V Murhekar, Nivedita Gupta, Alvira Z Hasan, Muthusamy Santhosh Kumar, V Saravana Kumar, Christine Prosperi, Gajanan N Sapkal, Jeromie Wesley Vivian Thangaraj, Ojas Kaduskar, Vaishali Bhatt and 31 more

Abstract read
In one paragraph

Article in The Lancet. Global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
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  13. Experiences and Lessons Learned from the Measles-Rubella Vaccination Campaign 2023 Implemented in Private Schools of Kolkata.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Manoj V MurhekarIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India. Electronic address: mmurhekar@nieicmr.org.in.
Nivedita GuptaDivision of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Alvira Z HasanInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Muthusamy Santhosh KumarIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
V Saravana KumarIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Christine ProsperiInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Gajanan N SapkalICMR-National Institute of Virology, Pune, India.
Jeromie Wesley Vivian ThangarajIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Ojas KaduskarICMR-National Institute of Virology, Pune, India.
Vaishali BhattICMR-National Institute of Virology, Pune, India.
Gururaj Rao DeshpandeICMR-National Institute of Virology, Pune, India.
Ullas Padinjaremattathil ThankappanICMR-National Institute of Virology, Pune, India.
Avi Kumar BansalICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
Sanjay L ChauhanICMR- National Institute for Research in Reproductive and Child Health, Mumbai, India.
Gangandeep Singh GroverDirectorate of Health Services, Government of Punjab, Chandigarh, India.
Arun Kumar JainICMR-National Institute of Pathology, New Delhi, India.
Ragini N KulkarniICMR- National Institute for Research in Reproductive and Child Health, Mumbai, India.
Santanu Kumar SharmaICMR-Regional Medical Research Centre, NE Region, Dibrugarh, India.
Itta K ChaaithanyaICMR- National Institute for Research in Reproductive and Child Health, Mumbai, India; Department of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
Sanchit KharwalDepartment of Health Research, Model Rural Health Research Unit-Hoshiarpur, Punjab, India.
Sunil K MishraDepartment of Health Research, Model Rural Health Research Unit-Hoshiarpur, Punjab, India.
Neha R SalviDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
Sandeep SharmaICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
Nilanju P SarmahDepartment of Health Research, Model Rural Health Research Unit-Chabua, Assam, India.
R SabarinathanIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Augustine DuraiswamyIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
D Sudha RaniIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
K KanagasabaiIndian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Abhishek LachyanDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
Poonam GawaliDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
Mitali KapoorDepartment of Health Research, Model Rural Health Research Unit-Dahanu, Maharashtra, India.
Arpit Kumar ShrivastavaICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
Saurabh Kumar ChonkerICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
Bipin TilekarICMR-National Institute of Virology, Pune, India.
Babasaheb V TandaleICMR-National Institute of Virology, Pune, India.
Mohammad AhmadWHO Country Office, New Delhi, India.
Lucky SangalWHO, Southeast Asia Region Office, New Delhi, India.
Amy WinterInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology and Statistics, University of Georgia, Athens, GA, USA.
Sanjay M MehendalePD Hinduja Hospital and Medical Research Centre, Mumbai, India.
William J MossInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kyla HayfordInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundIndia did phased measles-rubella supplementary immunisation activities (MR-SIAs; ie, mass-immunisation campaigns) targeting children aged 9 months to less than 15 years. We estimated measles-rubella seroprevalence before and after the MR-SIAs to quantify the effect on population immunity and identify remaining immunity gaps.

methodsBetween March 9, 2018 and March 19, 2020 we did community-based, cross-sectional serosurveys in four districts in India before and after MR-SIAs. 30 villages or wards were selected within each district, and one census enumeration block from each was selected as the survey cluster. Households were enumerated and 13 children in the younger age group (9 months to <5 years) and 13 children in the older ager group (5 to <15 years) were randomly selected by use of computer-generated random numbers. Serum samples were tested for IgG antibodies to measles and rubella viruses by enzyme immunoassay.

findingsSpecimens were collected from 2570 children before the MR-SIA and from 2619 children afterwards. The weighted MR-SIA coverage ranged from 73·7% to 90·5% in younger children and from 73·6% to 93·6% in older children. Before the MR-SIA, district-level measles seroprevalence was between 80·7% and 88·5% among younger children in all districts, and between 63·4% and 84·5% among older children. After the MR-SIA, measles seroprevalence among younger children increased to more than 90% (range 91·5 to 96·0) in all districts except Kanpur Nagar, in which it remained unchanged 80·4%. Among older children, measles seroprevalence increased to more than 90·0% (range 93·7% to 96·5%) in all districts except Hoshiarpur (88·7%). A significant increase in rubella seroprevalence was observed in all districts in both age groups, with the largest effect in Dibrugarh, where rubella seroprevalence increased from 10·6% to 96·5% among younger children.

interpretationMeasles-rubella seroprevalence increased substantially after the MR-SIAs but the serosurvey also identified remaining gaps in population immunity.

fundingThe Bill & Melinda Gates Foundation and Indian Council of Medical Research.

Indexed as

MeaslesRubellaAdolescentChildChild, PreschoolCross-Sectional StudiesHumansImmunoglobulin GIndiaInfantMass VaccinationSeroepidemiologic StudiesVaccinationImmunoglobulin G

Identifiers

PMID36240831
PMCPMC9579355

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