Evidence map›Paper›PMID 36240772›Full record

ArticleCurrent biology : CB2022

Sleep need-dependent changes in functional connectivity facilitate transmission of homeostatic sleep drive.

Margaret C W Ho, Masashi Tabuchi, Xiaojun Xie, Matthew P Brown, Skylar Luu, Serena Wang, Alex L Kolodkin, Sha Liu, Mark N Wu

Abstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Fly into tranquility: GABA's role in Drosophila sleep.Current opinion in insect science · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaret C W HoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Masashi TabuchiDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Xiaojun XieThe Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Matthew P BrownDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Skylar LuuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Serena WangDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alex L KolodkinDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sha LiuVIB Center for Brain & Disease Research and Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.
Mark N WuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: marknwu@jhmi.edu.

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Cross-Species Analyses of the Molecular and Circuit Basis ofSleepR35NS122181 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mark N Wu · 2021 to 2026
$6.9M
Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
Circuit Mechanisms Encoding Homeostatic Sleep DriveR01NS100792 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, MARK N · 2017 to 2020
$1.5M
Genetic mechanisms specifying astrocyte functional diversity and their role in sleepK99NS117654 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HO, MARGARET · 2020 to 2021
$175k
Mechanisms mediating the relationship between temporal coding and sleepK99NS101065 · NINDS · JOHNS HOPKINS UNIVERSITY · PI TABUCHI, MASASHI · 2018 to 2019
$167k
Functional and Developmental Analysis of Sleep Drive CircuitryF31NS117175 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BROWN, MATTHEW PHILIP · 2020 to 2022
$138k
NIH HHS P40 OD018537NINDS NIH HHS F31 NS117175NINDS NIH HHS K99 NS101065NINDS NIH HHS K99 NS117654NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS100792NINDS NIH HHS R35 NS122181NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

How the homeostatic drive for sleep accumulates over time and is released remains poorly understood. In Drosophila, we previously identified the R5 ellipsoid body (EB) neurons as putative sleep drive neurons

Indexed as

SleepSleep DeprivationAnimalsCholinergic AgentsCholinergic NeuronsDrosophilaHomeostasisCholinergic AgentsDrosophilaEPGhomeostaticplasticityR5sleepsleep drive

Identifiers

PMID36240772
PMCPMC9691613

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.