ArticleNeuron2022
Long-term learning transforms prefrontal cortex representations during working memory.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Long-term Learning Induces Plastic Changes in Frontostriatal Circuits.bioRxiv : the preprint server for biology · 2026Article
- Alpha phase coding supports feature binding during working memory maintenance.Communications biology · 2026Article
- Integrated Representations of Threat and Controllability in the Lateral Frontal Pole.Journal of cognitive neuroscience · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- Learning-dependent modulation of working memory.Memory & cognition · 2026Article
- Dynamics of working memory drift and information flow across the cortical hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Sensory reformatting for a working visual memory.Trends in cognitive sciences · 2025Review
- A Meta-Analysis of Task-Based fMRI Studies on Alcohol Use Disorder.Brain sciences · 2025Review
- Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory.NeuroImage · 2025Article
- Frontostriatal salience network expands as executive networks contract in Obsessive-Compulsive Disorder.bioRxiv : the preprint server for biology · 2025Article
- Supramodal and cross-modal representations of working memory in higher-order cortex.Nature communications · 2025Article
- When working memory works for our goals.eLife · 2025Article
- Stimulus representation in human frontal cortex supports flexible control in working memory.eLife · 2025Article
- Task structure tailors the geometry of neural representations in human lateral prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Using precision approaches to improve brain-behavior prediction.Trends in cognitive sciences · 2025Review
- Feedback scales the spatial tuning of cortical responses during both visual working memory and long-term memory.bioRxiv : the preprint server for biology · 2024Article
- Distinct functions for beta and alpha bursts in gating of human working memory.Nature communications · 2024Article
- Local organization of spatial and shape information in the primate prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
The role of the lateral prefrontal cortex (lPFC) in working memory (WM) is debated. Non-human primate (NHP) electrophysiology shows that the lPFC stores WM representations, but human neuroimaging suggests that the lPFC controls WM content in sensory cortices. These accounts are confounded by differences in task training and stimulus exposure. We tested whether long-term training alters lPFC function by densely sampling WM activity using functional MRI. Over 3 months, participants trained on both a WM and serial reaction time (SRT) task, wherein fractal stimuli were embedded within sequences. WM performance improved for trained (but not novel) fractals and, neurally, delay activity increased in distributed lPFC voxels across learning. Item-level WM representations became detectable within lPFC patterns, and lPFC activity reflected sequence relationships from the SRT task. These findings demonstrate that human lPFC develops stimulus-selective responses with learning, and WM representations are shaped by long-term experience, which could reconcile competing accounts of WM functioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.