ArticleProceedings of the National Academy of Sciences of the United States of America2022
5-methylcytosine (m
Open access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 68 citations in OpenAlex.
- PRMT5-mediated intron retention triggers innate and adaptive immunity against cancer.EMBO molecular medicine · 2026Article
- NSUN2-mediated m5C modification of HIV-1 RNA enables evasion of RIG‑I‑dependent innate immunity.PLoS pathogens · 2026Article
- YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2-m5C Modified ATF4 mRNA.Cancer science · 2026Article
- NSUN2‑mediated epitranscriptomic and ubiquitin modulation of Nipah virus matrix protein reveals a dual-targeting antiviral strategy.Protein & cell · 2026Article
- Dynamic tRNA modification landscapes reveal METTL1 in fibroblasts as a central regulator of aging.Science China. Life sciences · 2026Article
- Article
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- Transcriptomic and RNA Modification Landscape of Severe Fever with Thrombocytopenia Syndrome Virus Revealed by Nanopore Direct RNA Sequencing.Microorganisms · 2026Article
- Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- m5C RNA methylation is dysregulated by oncogenic herpesviruses via c-Myc signaling to counteract host antiviral factors.Nucleic acids research · 2026Article
- Enhancing plant antiviral responses and productivity through the elimination of mScience advances · 2026Article
- PUS1 Drives Renal Cancer Progression by Preventing Formation of Endogenous Double-stranded RNAs.International journal of biological sciences · 2026Article
- NSUN2-Mediated mInternational journal of general medicine · 2026Review
- RNA methylation in autoimmune rheumatic diseases: mechanisms and therapeutic potential.Frontiers in immunology · 2026Review
- RNA modifications in health and disease: from mechanistic insights to therapeutic applications.Precision clinical medicine · 2025Review
- RNA m5C methylation in cancer: mechanisms and biological impact.Oncogenesis · 2025Review
- Analysis of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Interactome.Journal of proteome research · 2025Article
- The RIG-I-like receptor family of immune proteins.Molecular cell · 2025Review
- Development of SARS-CoV-2 as a viral vector: A novel intranasal bivalent vaccine for SARS-CoV-2 and RSV.Science advances · 2025Article
- Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases.Journal of inherited metabolic disease · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Yuexiu ZhangDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Li-Sheng ZhangDepartment of Chemistry, The University of Chicago, Chicago, IL 60637.
Qing DaiDepartment of Chemistry, The University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8578-1568
Phylip ChenCenter for Vaccines and Immunity, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205.
Mijia LuDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Elizabeth L KairisDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Valarmathy MurugaiahDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Jiayu XuDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-0252-839X
Rajni Kant ShuklaDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-5722-449X
Xueya LiangDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Zhongyu ZouDepartment of Chemistry, The University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7152-5435
Estelle Cormet-BoyakaDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Jianming QiuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0001-9850-1695
Mark E PeeplesCenter for Vaccines and Immunity, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205.ORCID 0000-0002-4582-317X
Amit SharmaDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-3836-5617
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL 60637.
Jianrong LiDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
The Ohio State University · USUniversity of Chicago · USNationwide Children's Hospital · USHoward Hughes Medical Institute · USUniversity of Kansas Medical Center · US
Funding
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MProject 3: Dr. LiP01AI112524 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI PEEPLES, MARK E., RAMILO, OCTAVIO · 2015 to 2019
$6.8MMessenger RNA Capping and Methylation in PneumovirusesR01AI090060 · NIAID · OHIO STATE UNIVERSITY · PI LI, JIANRONG · 2011 to 2023
$4.0MBase-resolution sequencing of m6A in RNAR01HG008688 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2015 to 2017
$1.3MHost innate immune response as a barrier to cross-species retrovirus transmissionR00AI125136 · NIAID · OHIO STATE UNIVERSITY · PI SHARMA, AMIT · 2019 to 2020
$498kMessenger RNA capping and methylation in pneumovirusesR56AI090060 · NIAID · OHIO STATE UNIVERSITY · PI LI, JIANRONG, NIEWIESK, STEFAN · 2010 to 2010
$373kHost Innate Immune Response as a Barrier to Cross-Species Retrovirus TransmissionK99AI125136 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SHARMA, AMIT · 2016 to 2017
$194kHoward Hughes Medical InstituteNHGRI NIH HHS R01 HG008688NHGRI NIH HHS RM1 HG008935NIAID NIH HHS K99 AI125136NIAID NIH HHS P01 AI112524NIAID NIH HHS R00 AI125136NIAID NIH HHS R01 AI090060NIAID NIH HHS R56 AI090060
Abstract
5-methylcytosine (m
Indexed as
Interferon Type IVirus Diseases5-MethylcytosineAnimalsDEAD Box Protein 58HumansImmunity, InnateInterferonsLigandsMiceRNA Polymerase IIIVirus Replication5-MethylcytosineDEAD Box Protein 58InterferonsInterferon Type ILigandsRNA Polymerase III5-methylcytosineinnate immune responseinterferonvirus infection
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.