Evidence map›Paper›PMID 36240263›Full record

ReviewEnvironmental science & technology2022

Potential Artifacts and Control Experiments in Toxicity Tests of Nanoplastic and Microplastic Particles.

Elijah J Petersen, Ana C Barrios, Theodore B Henry, Monique E Johnson, Albert A Koelmans, Antonio R Montoro Bustos, Joanna Matheson, Matthias Roesslein, Jian Zhao, Baoshan Xing

Open access · greenAbstract readReview
In one paragraph

Review in Environmental science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Tracking of [Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. The Toxicity of Microplastics Explorer (ToMEx) 2.0.Microplastics and nanoplastics · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Elijah J PetersenMaterial Measurement Laboratory, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.ORCID 0000-0001-8215-9127
Ana C BarriosMaterial Measurement Laboratory, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.
Theodore B HenrySchool of Energy, Geoscience, Infrastructure and Society, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom.ORCID 0000-0002-9675-9454
Monique E JohnsonMaterial Measurement Laboratory, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.ORCID 0000-0001-5096-2003
Albert A KoelmansAquatic Ecology and Water Quality Management group, Wageningen University & Research, 6700 AA Wageningen, The Netherlands.ORCID 0000-0001-7176-4356
Antonio R Montoro BustosMaterial Measurement Laboratory, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.ORCID 0000-0001-5945-2333
Joanna MathesonUS Consumer Product Safety Commission, 5 Research Place, Rockville, Maryland 20850, United States.
Matthias RoessleinEmpa, Swiss Federal Laboratories for Material Testing and Research, Particles-Biology Interactions Laboratory, CH-9014 St. Gallen, Switzerland.
Jian ZhaoInstitute of Coastal Environmental Pollution Control, Ministry of Education Key Laboratory of Marine Environment and Ecology, and Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao 266100, China.ORCID 0000-0002-4971-5643
Baoshan XingStockbridge School of Agriculture, University of Massachusetts, Amherst, Massachusetts 01003, United States.ORCID 0000-0003-2028-1295
National Institute of Standards and Technology · USHeriot-Watt University · GBOcean University of China · CNSwiss Federal Laboratories for Materials Science and Technology · CHUnited States Consumer Product Safety Commission · USUniversity of Massachusetts Amherst · USWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To fully understand the potential ecological and human health risks from nanoplastics and microplastics (NMPs) in the environment, it is critical to make accurate measurements. Similar to past research on the toxicology of engineered nanomaterials, a broad range of measurement artifacts and biases are possible when testing their potential toxicity. For example, antimicrobials and surfactants may be present in commercially available NMP dispersions, and these compounds may account for toxicity observed instead of being caused by exposure to the NMP particles. Therefore, control measurements are needed to assess potential artifacts, and revisions to the protocol may be needed to eliminate or reduce the artifacts. In this paper, we comprehensively review and suggest a next generation of control experiments to identify measurement artifacts and biases that can occur while performing NMP toxicity experiments. This review covers the broad range of potential NMP toxicological experiments, such as

Indexed as

MicroplasticsWater Pollutants, ChemicalAnimalsArtifactsHumansMammalsPlasticsToxicity TestsMicroplasticsPlasticsWater Pollutants, Chemicalartifactscontrol experimentsmeasurement qualitymicroplasticsnanoplastics

Identifiers

PMID36240263
PMCPMC10476161
OpenAlexW4306194582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.