Observational studyPloS one2022
Post-intensive care syndrome in out-of-hospital cardiac arrest patients: A prospective observational cohort study.
Observational study in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Prevalence and incidence of post-intensive care syndrome among intensive care unit survivors: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- Recovery Phase in the Chain of Survival in Cardiac Arrest Patients: Scoping Review.The Malaysian journal of medical sciences : MJMS · 2026Review
- Association between red blood cell distribution width to albumin ratio (RAR) and long-term prognosis of patients with sudden cardiac arrest.Journal of thoracic disease · 2025Article
- Depression or anxiety and long-term mortality among adult survivors of intensive care unit: a population-based cohort study.Critical care (London, England) · 2025Article
- The Prognosis After Cardiac Arrest: Evidence on the Short- and Long-Term Course.Deutsches Arzteblatt international · 2025Review
- Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis.Critical care (London, England) · 2025Article
- Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies.Annals of intensive care · 2025Review
- Prediction of outcomes after cardiac arrest by a generative artificial intelligence model.Resuscitation plus · 2024Article
- Post-intensive care syndrome and health-related quality of life in long-term survivors of cardiac arrest: a prospective cohort study.Scientific reports · 2024Article
- Changes in temporal muscle dimensions and their clinical impact in out-of-hospital cardiac arrest survivors.Resuscitation plus · 2024Article
- Trend of Outcome Metrics in Recent Out-of-Hospital-Cardiac-Arrest Research: A Narrative Review of Clinical Trials.Journal of clinical medicine · 2023Review
- Red blood cell distribution width for the prediction of outcomes after cardiac arrest.Scientific reports · 2023Article
- Predictors of neurocognitive and psychological disorders in children after intensive care admission: A prospective cohort study.Health science reports · 2023Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntensive care unit patients are at risk for post-intensive care syndrome (PICS), which includes psychological, physical and/or cognitive sequelae after their hospital stay. Our aim was to investigate PICS in adult patients with out-of-hospital cardiac arrest (OHCA).
methodsIn this prospective observational cohort study, we assessed risks for PICS at 3 and 12-month follow-up within the following domains: a) physical impairment (EuroQol [EQ-5D-3L]), b) cognitive functioning (Cerebral Performance Category [CPC] score >1, modified Rankin Scale [mRS] >2) and c) psychological burden (Hospital Anxiety and Depression Scale [HADS], Impact of Event Scale-Revised [IES-R]).
resultsAt 3 months, 69/139 patients (50%) met the definition of PICS including 37% in the physical domain, 25% in the cognitive domain and 13% in the psychological domain. Intubation (OR 2.3, 95%CI 1.1 to 5,0 p = 0.03), sedatives (OR 3.4, 95%CI 1 to 11, p = 0.045), mRS at discharge (OR 4.3, 95%CI 1.70 to 11.01, p = 0.002), CPC at discharge (OR 3.3, 95%CI 1.4 to 7.6, p = 0.005) and post-discharge work loss (OR 13.4, 95%CI 1.7 to 107.5, p = 0.014) were significantly associated with PICS. At 12 months, 52/110 (47%) patients had PICS, which was associated with prolonged duration of rehabilitation, higher APACHE scores, and higher mRS and CPC scores at hospital discharge.
conclusionsNearly half of long-term OHCA survivors show PICS after 3 and 12 months. These high numbers call for more emphasis on appropriate screening and treatment in this patient population. Future studies should evaluate whether early identification of these patients enables preventive strategies and treatment options.
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