Evidence map›Paper›PMID 36240101›Full record

ArticleNeurology2022

Epilepsy, Vascular Risk Factors, and Cognitive Decline in Older Adults: The Cardiovascular Health Study.

Hyunmi Choi, Mitchell S V Elkind, W T Longstreth, Amelia K Boehme, Rebekah Hafen, Emma J Hoyt, Evan L Thacker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hyunmi ChoiFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT. hc323@columbia.edu.
Mitchell S V ElkindFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT.ORCID 0000-0003-2562-1156
W T LongstrethFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT.
Amelia K BoehmeFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT.ORCID 0000-0002-7109-6025
Rebekah HafenFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT.
Emma J HoytFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT.
Evan L ThackerFrom the Department of Neurology (H.C., M.S.V.E., A.K.B.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E., A.K.B.), Mailman School of Public Health, Columbia University, New York; Department of Neurology (W.T.L.), University of Washington, Seattle; and Department of Public Health (R.H., E.J.H., E.L.T.), Brigham Young University, Provo, UT.
Brigham Young University · US

Funding

CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114
6 · The paper itself

Abstract

BACKGROUND AND

objectivesRecent studies have shown that global cognitive ability tends to decline faster over time in older adults (≥65 years) with epilepsy compared with older adults without epilepsy. Scarce data exist about the role of vascular risk factors (VRFs) on cognitive course in epilepsy. We assessed whether the associations of individual VRFs with cognitive trajectory differed depending on the presence of prevalent epilepsy.

methodsThe Cardiovascular Health Study is a population-based longitudinal cohort study of 5,888 US adults aged ≥65 years. Cognitive function was assessed annually with modified Mini-Mental State Examination (3MS; global cognitive ability) and Digit Symbol Substitution Test (DSST; information processing speed). We used linear mixed models to estimate the individual and joint associations of epilepsy and VRFs with cognitive decline by modeling epilepsy × VRF interactions one by one, each adjusted for all other VRFs considered, including demographics, health behaviors, clinical characteristics, and comorbid diagnoses. From these models, we estimated excess mean cognitive decline due to interaction of epilepsy with each VRF.

resultsWe observed excess mean decline in global cognitive ability (3MS) due to interactions of epilepsy with hypertension (6.6 points greater mean 8-year decline than expected if no interaction; 95% CI 1.3-12.0) and with abstaining from alcohol (5.8 points greater than expected; 95% CI 0.3-11.3). We also observed excess mean decline in information processing speed (DSST) due to interactions of epilepsy with prior stroke (18.1 points greater mean 9-year decline than expected; 95% CI 7.6-28.5), with abstaining from alcohol (6.1 points greater than expected; 95% CI 2.5-9.8), and with higher triglyceride levels (2.4 points greater than expected per SD; 95% CI 0.4-4.3). DISCUSSION: Associations of some VRFs with cognitive decline in older adults are stronger in the presence of epilepsy, suggesting a need for greater attention to vascular protection for preserving brain health in older adults with epilepsy.

Indexed as

Cognitive DysfunctionEpilepsyAgedCognitionHumansLongitudinal StudiesNeuropsychological TestsRisk Factors

Identifiers

PMID36240101
PMCPMC9687405
OpenAlexW4294335366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.