Observational studyAdvances in therapy2022
The Hidden Burden of Disease and Treatment Experiences of Patients with Essential Tremor: A Retrospective Claims Data Analysis.
Observational study in Advances in therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Peripheral nerve stimulation for essential tremor: a GRADE-assessed systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Efficacy and Safety of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy in Essential Tremor: A Systematic Review and Metanalysis.Movement disorders : official journal of the Movement Disorder Society · 2025Pooled it
- Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Trial
- Efficacy and Safety of the Felix NeuroAI Wristband for Essential Tremor: Results of a 1-Year Open-Label Extension Trial.Movement disorders clinical practice · 2026Article
- Epidemiology and Treatment of Patients with Essential Tremor: A Retrospective Cohort Analysis in the United Kingdom.Neuroepidemiology · 2026Article
- Comparative Efficacy of Acupuncture Therapy in Primary Essential Tremor: A Network Meta-Analysis and Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Safety and Effectiveness of Unilateral Transcranial Magnetic Resonance-Guided Focused Ultrasound in Essential Tremor: One-Year Single-Center Real-World Results.Neurology international · 2025Article
- Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database.Scientific reports · 2025Article
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics.Brain sciences · 2025Review
- Prevalence of Diagnosed Essential Tremor in the United States: An Administrative Claims-Based Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Unilateral magnetic resonance-guided focused ultrasound for medication-refractory essential tremor: 5-year continued access study.Frontiers in neurology · 2025Article
- Epidemiology and treatment patterns of essential tremor: a retrospective cohort analysis in Germany.Frontiers in neurology · 2025Article
- Review
- Prescription Drug Utilization among Patients with Essential Tremor: A Cross-Sectional Study of More Than 36,000 Patients.Movement disorders clinical practice · 2024Article
- Review
- Validation of the International Classification of Diseases, Tenth Revision-Clinical Modification Diagnostic Code for Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Reasons for Hospitalizations and Emergency Department Visits Among Patients with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Clinical and Economic Correlates of Pharmacotherapy in Patients with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Treatment patterns in essential tremor: Real-world evidence from a United Kingdom and France primary care database.European journal of neurology · 2024Article
- T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.Annals of clinical and translational neurology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEssential tremor (ET) affects approximately 7 million people in the USA, yet public recognition of the disease and its impact remain low.
methodsA retrospective observational study examined US claims data from 2015 to 2019 using the Compile database. ET diagnoses were captured using longitudinal data from 2015 to 2019 and for the year 2019, with diagnosis estimates extrapolated to the general US population. Confirmed ET was identified by an ET diagnosis code with at least two relevant prescriptions or by two diagnosis codes for ET and unspecified tremor at least 90 days apart. Comorbidity and treatment use data were extracted, and medication compliance and 2-year treatment persistence were assessed as measures of treatment adherence.
resultsA total of 1,336,183 patients with ET diagnoses codes were identified from 2015 through 2019, corresponding to 2,226,971 projected US diagnoses. In 2019, 128,263 patients had a confirmed ET diagnosis, corresponding to 213,772 projected US confirmed diagnoses. Of these, 96% had at least one comorbidity, and 64% received at least one pharmacologic treatment. Propranolol (24%) and primidone (20%) comprised the most common ET prescriptions. Two-year medication discontinuation rates were approximately 40%.
conclusionOur findings revealed that 1 million people were diagnosed and sought treatment for ET in the USA from 2015 to 2019. Projected population estimates of approximately 2 million people diagnosed suggest a further 1 million remain untreated. Our findings highlight the complexity of patient care in ET, complicated by delayed diagnoses, multiple comorbidities, and lack of effective and tolerable therapies that can mitigate treatment adherence limitations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.