ArticleAging clinical and experimental research2022
Frailty, multimorbidity patterns and mortality in institutionalized older adults in Italy.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial.Nature aging · 2026Trial
- Multidimensional Symptom Burden Among Institutionalised Older Adults: Associations with Functional Status, Psychological Factors and Quality of Life.Healthcare (Basel, Switzerland) · 2026Article
- Feeding tube dependence and postoperative complications in older adults after head and neck cancer surgery: a retrospective cohort study.BMC geriatrics · 2026Article
- Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults.BMC medicine · 2026Article
- Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia.Drugs & aging · 2025Article
- Comorbidity and medication patterns in atrial fibrillation patients: association with adverse clinical outcomes.Internal and emergency medicine · 2025Article
- Weekend catch-up sleep and frailty in US adults: a cross-sectional study from NHANES 2017-2020.BMC public health · 2025Article
- Exploring patterns of multimorbidity in South Korea using exploratory factor analysis and non negative matrix factorization.Scientific reports · 2025Article
- Frailty and 12-month mortality among older adults with type 2 diabetes in nursing homes: A longitudinal study.PloS one · 2025Article
- Essential New Complexity-Based Themes for Patient-Centered Diagnosis and Treatment of Dementia and Predementia in Older People: Multimorbidity and Multilevel Phenomenology.Journal of clinical medicine · 2024Review
- Diagnosis of frailty and implications on surgical process in the elderly: A narrative review.European journal of anaesthesiology and intensive care · 2023Review
- A comprehensive review of machine learning algorithms and their application in geriatric medicine: present and future.Aging clinical and experimental research · 2023Review
- Medication use in Italian nursing homes: preliminary results from the national monitoring system.Frontiers in pharmacology · 2023Article
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7 authors.
Funding
Abstract
backgroundLittle is known on how frailty influences clinical outcomes in persons with specific multimorbidity patterns.
aimsTo investigate the interplay between multimorbidity and frailty in the association with mortality in older individuals living in nursing homes (NH).
methodsWe considered 4,131 NH residents aged 60 years and over, assessed through the interRAI LTCF instrument between 2014 and 2018. Follow-up was until 2019. Considering four multimorbidity patterns identified via principal component analysis, subjects were stratified in tertiles (T) with respect to their loading values. Frailty Index (FI) considered 23 variables and a cut-off of 0.24 distinguished between high and low frailty levels. For each pattern, all possible combinations of tertiles and FI were evaluated. Their association (Hazard Ratio [HR] and 95% confidence interval) with mortality was tested in Cox regression models.
resultsIn the heart diseases and dementia and sensory impairments patterns, the hazard of death increases progressively with patterns expression and frailty severity (being HR T3 vs. T1 = 2.36 [2.01-2.78]; HR T3 vs. T1 = 2.12 [1.83-2.47], respectively). In heart, respiratory and psychiatric diseases and diabetes, musculoskeletal and vascular diseases patterns, frailty seems to have a stronger impact on mortality than patterns' expression. DISCUSSION: Frailty increases mortality risk in all the patterns and provides additional prognostic information in NH residents with different multimorbidity patterns.
conclusionsThese findings support the need to routinely assess frailty. Older people affected by specific groups of chronic diseases need a specific care approach and have high risk of negative health outcomes.
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