ArticleGenes & genomics2022
Genome-wide identification and expression analysis of the aquaporin gene family reveals the role in the salinity adaptability in Nile tilapia (Oreochromis niloticus).
Article in Genes & genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 7 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNile tilapia (Oreochromis niloticus), an important economic freshwater fish being cultured globally, is highly adaptable to a wide range of salinities. However, little information is currently available on the mechanism of salinity adaptation.
objectiveFor a better understanding of this intriguing adaptability, we identified and analyzed aquaporins (AQPs), which are channel proteins with a basic function of intracellular and intercellular transportation for water and certain solutes.
methodsIn the present study, we performed genome-wide identification and comprehensive analysis of the duplicated AQP genes in Nile tilapia by bioinformatics methods. Tissue-specific analyses were then combined with transcriptome data under different salinity treatments.
resultsIt was revealed that Nile tilapia has a total of twenty-eight AQPs, which are distributed unevenly on twelve chromosomes and belong to four subfamilies according to phylogenetic analysis. These AQPs share conserved AQP characteristic structural domains and motifs, although they differ in molecular weight from 23 to 36 kDa and contain distinct sequences. GO analysis revealed that most AQPs have transporter protein activity and are involved in biological processes such as substance transport, stress response, development and metabolism. KEGG enrichment analysis showed that AQPs were significantly enriched in two pathways, anti-diuretic hormone-regulated reabsorption and bile secretion.
conclusionThese results suggested that Nile tilapia has a highly developed, albeit complex, osmotic pressure regulation system, which provided a molecular basis for exploring how these AQP members coordinate to help Nile tilapia cope with different salinities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.