Evidence map›Paper›PMID 36239840›Full record

ArticleBreast cancer research and treatment2022

Oncologic safety of axillary lymph node dissection with immediate lymphatic reconstruction.

Hope M Guzzo, Stephanie A Valente, Graham S Schwarz, Ayat ElSherif, Stephen R Grobmyer, Cagri Cakmakoglu, Risal Djohan, Steven Bernard, Julie E Lang, Debra Pratt and 1 more

Abstract read
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In one paragraph

Article in Breast cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hope M GuzzoDivision of Breast Surgery, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Stephanie A ValenteDivision of Breast Surgery, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Graham S SchwarzDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH, USA.
Ayat ElSherifDivision of Breast Surgery, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Stephen R GrobmyerCleveland Clinic Abu Dhabi, Oncology Institute, Abu Dhabi, United Arab Emirates.
Cagri CakmakogluDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH, USA.
Risal DjohanDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH, USA.
Steven BernardDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH, USA.
Julie E LangDivision of Breast Surgery, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Debra PrattDivision of Breast Surgery, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Zahraa Al-HilliDivision of Breast Surgery, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. alhillz@ccf.org.ORCID http://orcid.org/0000-0003-2383-0499
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImmediate lymphatic reconstruction (ILR) at the time of axillary lymph node dissection (ALND) can reduce the incidence of lymphedema in patients with breast cancer. The oncologic safety of ILR is unknown and has not been reported. The purpose of this study was to evaluate if ILR is associated with increased breast cancer recurrence rates.

methodsPatients with breast cancer who underwent ALND with ILR from September 2016 to December 2020 were identified from a prospective institutional database. Patient demographics, tumor characteristics, and operative details were recorded. Follow-up included the development of local recurrence as well as distant metastasis. Oncologic outcomes were analyzed.

resultsA total of 137 patients underwent ALND with ILR. At cancer presentation, 122 patients (89%) had clinically node positive primary breast cancer, 10 patients (7.3%) had recurrent breast cancer involving the axillary lymph nodes, 3 patients (2.2%) had recurrent breast cancer involving both the breast and axillary nodes, and 2 patients (1.5%) presented with axillary disease/occult breast cancer. For surgical management, 103 patients (75.2%) underwent a mastectomy, 22 patients (16%) underwent lumpectomy and 12 patients (8.8%) had axillary surgery only. The ALND procedure, yielded a median of 15 lymph nodes pathologically identified (range 3-41). At a median follow-up of 32.9 months (range 6-63 months), 17 patients (12.4%) developed a local (n = 1) or distant recurrence (n = 16), however, no axillary recurrences were identified.

conclusionImmediate lymphatic reconstruction in patients with breast cancer undergoing ALND is not associated with short term axillary recurrence and appears oncologically safe.

Indexed as

Breast NeoplasmsFemaleHumansLymphatic MetastasisLymph Node ExcisionLymph NodesMastectomyNeoplasm Recurrence, LocalProspective StudiesSentinel Lymph Node BiopsyAxillary lymph node dissectionImmediate lymphatic reconstructionLYMPHALymphedemaLymphovenous bypass

Identifiers

PMID36239840
OpenAlexW4306156599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.