ReviewPhysiological reviews2023
Multisystem physiological perspective of human frailty and its modulation by physical activity.
Review in Physiological reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
117 citing papers in PubMed, 5 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- The safety, acceptability, and effectiveness of home-based 'exercise snacking' for improving physical function of older adults: a systematic review.European geriatric medicine · 2026Pooled it
- Frailty in peritoneal dialysis patients: a scoping review.Frontiers in medicine · 2026Pooled it
- Effects of Exergaming on Frailty: A Systematic Review and Meta-Analysis.Journal of clinical nursing · 2025Pooled it
- Is frailty associated with increased concerns about falling and activity restriction in community-dwelling older adults? A systematic review.The Journal of frailty & aging · 2025Pooled it
- Association of frailty and pre-frailty with cardiovascular mortality: a meta-analysis of 26 cohort studies.Frontiers in public health · 2025Pooled it
- Multidisciplinary intervention in frail elderly patients with cardiovascular diseases: a multicentre, single-blinded, randomised controlled trial.Nature communications · 2026Trial
- Experiences of participating in a preoperative comprehensive geriatric assessment and care intervention among frail older adults before colorectal cancer resection surgery.BMC geriatrics · 2025Trial
- Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on EDDrug design, development and therapy · 2024Trial
- Frailty index and type 2 diabetes with renal complications: insights from Mendelian randomization and retrospective observational study.Renal failure · 2026Observational
- Optimizing frailty care: an analysis of dual exercise targets and cognitive function among frail older adults.GeroScience · 2026Article
- The Role of Spiritual Well-Being in the Relationship Between Frailty and Hopelessness Among Older Adults in Türkiye.Journal of religion and health · 2026Article
- Effect of bodyweight interval training on frailty status in older adults: a randomized controlled trial.European geriatric medicine · 2026Article
- Multidimensional Frailty and Resilience in Relation to Quality of Life in Senior Patients with Cardiovascular Disease: An Exploratory Cross-Sectional Pilot Study.Journal of clinical medicine · 2026Article
- Individualised but Specific Exercise Training Improves Physiologic Reserve and Reduces Frailty in Older Adults with Chronic Lymphocytic Leukaemia: A 12-Week Pragmatic Randomised Controlled Trial.medRxiv : the preprint server for health sciences · 2026Article
- Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide.Scientific reports · 2026Article
- Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026Review
- Functional decline in the final years of life: A multicohort study.BMC medicine · 2026Article
- A predictive tool incorporating frailty scores for perioperative risk assessment in patients with spinal metastasis: a national retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The joint association of sleep duration and physical activity with frailty among older adults: the first evidence from CHARLS.BMC geriatrics · 2026Article
- How health literacy and eHealth literacy influence quality of life in older adults with chronic diseases: a network and path analysis.Health and quality of life outcomes · 2026Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
"Frailty" is a term used to refer to a state characterized by enhanced vulnerability to, and impaired recovery from, stressors compared with a nonfrail state, which is increasingly viewed as a loss of resilience. With increasing life expectancy and the associated rise in years spent with physical frailty, there is a need to understand the clinical and physiological features of frailty and the factors driving it. We describe the clinical definitions of age-related frailty and their limitations in allowing us to understand the pathogenesis of this prevalent condition. Given that age-related frailty manifests in the form of functional declines such as poor balance, falls, and immobility, as an alternative we view frailty from a physiological viewpoint and describe what is known of the organ-based components of frailty, including adiposity, the brain, and neuromuscular, skeletal muscle, immune, and cardiovascular systems, as individual systems and as components in multisystem dysregulation. By doing so we aim to highlight current understanding of the physiological phenotype of frailty and reveal key knowledge gaps and potential mechanistic drivers of the trajectory to frailty. We also review the studies in humans that have intervened with exercise to reduce frailty. We conclude that more longitudinal and interventional clinical studies are required in older adults. Such observational studies should interrogate the progression from a nonfrail to a frail state, assessing individual elements of frailty to produce a deep physiological phenotype of the syndrome. The findings will identify mechanistic drivers of frailty and allow targeted interventions to diminish frailty progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.