ArticleJournal of veterinary internal medicine2022
Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Evaluation of sequential serum amyloid A measurements for the prediction of sepsis and survival in critically ill neonatal foals.Journal of veterinary internal medicine · 2026Article
- Sequential measurement of serum amyloid A concentrations in ill hospitalized neonatal foals.Journal of veterinary internal medicine · 2026Article
- The predictive ability of blood-based biomarkers to detect bacteremia in hospitalized neonatal foals.Veterinary journal (London, England : 1997) · 2025Article
- Interleukin-27-producing cells in gram-negative neonatal sepsis display diverse phenotypes and functions in the liver.ImmunoHorizons · 2025Article
- Effect of Simple Oral Dental Extraction on Systemic Serum Amyloid A Concentrations in Horses.Veterinary medicine and science · 2024Article
- A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients.Scientific reports · 2024Observational
- Article
- Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals.Journal of veterinary internal medicine · 2022Article
- Retrospective cohort study on diseases and risk factors associated with death in hospitalized neonatal foals.Journal of veterinary internal medicineArticle
- The Systemic Inflammatory Response Syndrome and Predictors of Infection and Mortality in 1068 Critically Ill Newborn Foals.Journal of veterinary internal medicineArticle
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Authors and funding
12 authors at 6 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum amyloid A (SAA) has been reported to hold promise as diagnostic and prognostic marker in foals. This has not been investigated thoroughly.
objectivesEvaluate admission SAA concentrations as predictor of sepsis and outcome. ANIMALS: Five hundred and ninety hospitalized foals <14 days old.
methodsRetrospective multicenter study. Foals were scored with sepsis and survival scores, grouped according to health category (septic, sick but nonseptic, uncertain sepsis status) and outcome; septic foals were further categorized according to severity (normal sepsis, severe sepsis, and septic shock). SAA was compared between groups using Mann-Whitney test and Kruskal-Wallis test. Receiver operating characteristic curves identified optimal SAA cut off values for detecting sepsis and predicting outcome.
resultsAdmission SAA concentrations differed significantly between sick nonseptic foals (312.1 ± 685.4 mg/L) and septic foals (1079.7 ± 1254.5 mg/L) and increased with increasing sepsis score. SAA did not differ between sepsis severity groups. The optimal cut off for sepsis detection was 1050 mg/L (sensitivity 30.2%, specificity 90.7%). Admission SAA concentrations were lower in surviving (435.0 ± 723.6 mg/L) compared to nonsurviving foals (1062.7 ± 1440.1 mg/L) and decreased with increasing survival score. The optimal cut off for nonsurvival prediction was 1250 mg/L (sensitivity 22.1%, specificity 90.8%). CONCLUSIONS AND CLINICAL IMPORTANCE: SAA concentration was higher in septic foals and nonsurviving foals. Even though optimal cut offs for SAA to detect sepsis and predict outcome had low sensitivity, they had good specificity. SAA can therefore be used as a marker to rule out sepsis and nonsurvival.
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