Evidence map›Paper›PMID 36239072›Full record

ArticlePharmacotherapy2022

A nationwide study of multimedicine use in people treated with cardiovascular medicines in Australia.

Andrea L Schaffer, Joel Chia, Jonathan Brett, Sallie-Anne Pearson, Michael O Falster

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Persistence and Adherence to Cardiovascular Medicines in Australia.Journal of the American Heart Association · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrea L SchafferCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-3701-4997
Joel ChiaCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.
Jonathan BrettCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-3065-7495
Sallie-Anne PearsonCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-7137-6855
Michael O FalsterCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-6444-7272
UNSW Sydney · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectiveMultimorbidity and multimedicine use are common in people with cardiovascular disease and can lead to harms, such as prescribing errors and drug interactions. We quantified multimedicine use in people treated with cardiovascular medicines in a national sample of Australians.

designCross-sectional study. DATA SOURCE: Pharmaceutical dispensing claims for a 10% random sample of Australians. PATIENTS: Australian adults dispensed any cardiovascular medicine between June and August 2019.

interventionNone. MEASUREMENTS: We quantified the number and type of cardiovascular and non-cardiovascular medicines dispensed during the study period, and the number of unique prescribers, by age and sex. MAIN

resultsWe identified 493,081 people dispensed any cardiovascular medicine (median age = 67 years, 50.2% women). The population prevalence of cardiovascular medicine dispensing increased from 1.7% (n = 10,503) in people 18-34 years to 80.1% (n = 99,271) in people 75-84 years. Cardiovascular medicine dispensing varied by sex; women 18-34 years were more likely to be dispensed any cardiovascular medicine than men (male:female prevalence ratio [PR] = 0.84, 95% confidence interval [CI] = 0.81-0.87), whereas the prevalence of cardiovascular medicine dispensing was higher in men 35-44 years (PR = 1.27, 95% CI 1.24-1.30) and 45-54 years (PR = 1.24, 95% CI 1.22-1.26) and was similar between sexes in people ≥65 years. Overall, both women and men were dispensed a median of 2.0 (interquartile range [IQR] = 1.0-3.0) cardiovascular medicines. Two-thirds of people ≥65 years (73.5%; n = 208,524) were dispensed ≥2 cardiovascular medicines, with 16.6% (n = 6736) of people ≥85 years dispensed five or more. Women and men were dispensed a median of 2.0 (IQR = 1.0-5.0) and 2.0 (IQR = 0.0-4.0) non-cardiovascular medicines, respectively, to treat comorbid conditions, commonly gastroesophageal reflux disease medicines (32.2% of women and 26.6% of men), antibiotics (28.7% of women and 22.4% of men), and antidepressants (26.3% of women and 15.9% of men). One quarter of both sexes had multiple prescribers for their cardiovascular medicines alone, whereas 54.5% (n = 134,939) of women and 49.9% (n = 122,706) of men had multiple prescribers for all medicines.

conclusionMultimedicine use is common in people treated with cardiovascular medicines and presents a risk for inappropriate prescribing. Understanding the comorbid conditions commonly treated concurrently with cardiovascular disease can help improve co-prescribing guidelines and develop a person-centered approach to multimorbidity treatment.

Indexed as

Cardiovascular AgentsCardiovascular DiseasesAdultAgedAntidepressive AgentsAustraliaCross-Sectional StudiesDrug PrescriptionsFemaleHumansInappropriate PrescribingMaleAntidepressive AgentsCardiovascular AgentsAustraliacardiovascular diseasemultimorbiditypolypharmacy

Identifiers

PMID36239072
PMCPMC9828398
OpenAlexW4306247905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.