Evidence map›Paper›PMID 36238840›Full record

ArticleOncology letters2022

Cancer-associated gene analysis of cervical cytology samples and liquid-based cytology significantly improve endometrial cancer diagnosis sensitivity.

Ryo Nimura, Eiji Kondo, Kenta Yoshida, Michiko Kubo-Kaneda, Masafumi Nii, Makoto Ikeijiri, Maki Nakamura, Hiroshi Imai, Yoshinaga Okugawa, Kaname Nakatani and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ryo NimuraDepartment of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Eiji KondoDepartment of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Kenta YoshidaDepartment of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Michiko Kubo-KanedaDepartment of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Masafumi NiiDepartment of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Makoto IkeijiriDepartment of Genomic Medicine, Mie University School of Medicine, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Maki NakamuraDepartment of Genomic Medicine, Mie University School of Medicine, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Hiroshi ImaiPathology Division, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Yoshinaga OkugawaDepartment of Genomic Medicine, Mie University School of Medicine, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Kaname NakataniDepartment of Genomic Medicine, Mie University School of Medicine, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Tomoaki IkedaDepartment of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Mie University · JPMie University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To the best of our knowledge, there are no useful screening methods for early detection of endometrial cancer in asymptomatic individuals. The present study evaluated the usefulness of genetic analysis of liquid-based cytology (LBC) specimens by assessing whether pathological genetic mutations detected in cancer tissue sections were detected in LBC specimens from the cervix and uterus. The primary endpoint was genetic analysis of cervical cytology specimens and LBC for the detection of endometrial cancer. Endometrial thickening (>11 mm) assessed using transvaginal ultrasonography was present in 60% of cases and adenocarcinoma assessed using cervical cytology was present in 50% of cases. In 70% of cases, pathogenic mutations detected in cancer tissue sections were also detected in cervical and/or endometrial LBC specimens. The pathogenic variants identified were

Indexed as

cervical cytologyendometrial cancerliquid-based cytologynext-generation sequencing

Identifiers

PMID36238840
PMCPMC9494621
OpenAlexW4296118022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.