Evidence map›Paper›PMID 36238714›Full record

ArticlebioRxiv : the preprint server for biology2022

Ultra-deep Sequencing of Hadza Hunter-Gatherers Recovers Vanishing Gut Microbes.

Bryan D Merrill, Matthew M Carter, Matthew R Olm, Dylan Dahan, Surya Tripathi, Sean P Spencer, Brian Yu, Sunit Jain, Norma Neff, Aashish R Jha and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Bryan D MerrillDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Matthew M CarterDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Matthew R OlmDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Dylan DahanDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Surya TripathiDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Sean P SpencerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Brian YuChan Zuckerberg Biohub, San Francisco, CA, USA.
Sunit JainChan Zuckerberg Biohub, San Francisco, CA, USA.
Norma NeffChan Zuckerberg Biohub, San Francisco, CA, USA.
Aashish R JhaGenetic Heritage Group, Program in Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
Erica D SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Justin L SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.

Funding

MOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9M
Impact of Diet on Intestinal Microbiota-Host DynamicsR01DK085025 · NIDDK · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 2010 to 2026
$6.4M
Defining and Reconstructing the Human Ancestral MicrobiomeDP1AT009892 · NCCIH · STANFORD UNIVERSITY · PI SONNENBURG, JUSTIN L · 2017 to 2021
$5.5M
Understanding mechanisms by which microbial strains and metabolites in fermented foods decrease systemic inflammationF32DK128865 · NIDDK · STANFORD UNIVERSITY · PI OLM, MATTHEW RAYMOND · 2021 to 2023
$186k
NCCIH NIH HHS DP1 AT009892NIAID NIH HHS T32 AI007328NIDDK NIH HHS F32 DK128865NIDDK NIH HHS R01 DK085025
6 · The paper itself

Abstract

The gut microbiome is a key modulator of immune and metabolic health. Human microbiome data is biased towards industrialized populations, providing limited understanding of the distinct and diverse non-industrialized microbiomes. Here, we performed ultra-deep metagenomic sequencing and strain cultivation on 351 fecal samples from the Hadza, hunter-gatherers in Tanzania, and comparative populations in Nepal and California. We recover 94,971 total genomes of bacteria, archaea, bacteriophages, and eukaryotes, 43% of which are absent from existing unified datasets. Analysis of

Identifiers

PMID36238714
PMCPMC9558438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.