Evidence map›Paper›PMID 36238691›Full record

ArticleFrontiers in cell and developmental biology2022

Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities.

Ann-Sofie De Meulemeester, Lise Heylen, Aleksandra Siekierska, James D Mills, Alessia Romagnolo, Nicole N Van Der Wel, Eleonora Aronica, Peter A M de Witte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Early death and neuronal abnormalities inbioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ann-Sofie De MeulemeesterLaboratory for Molecular Biodiscovery, KU Leuven, Leuven, Belgium.
Lise HeylenLaboratory for Molecular Biodiscovery, KU Leuven, Leuven, Belgium.
Aleksandra SiekierskaLaboratory for Molecular Biodiscovery, KU Leuven, Leuven, Belgium.
James D MillsDepartment of (Neuro)Pathology Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Alessia RomagnoloDepartment of (Neuro)Pathology Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Nicole N Van Der WelDepartment of Medical Biology, Electron Microscopy Center Amsterdam, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Eleonora AronicaDepartment of (Neuro)Pathology Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Peter A M de WitteLaboratory for Molecular Biodiscovery, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by pathogenic variants in

Indexed as

epilepsymTORneurodevelopmentRNA-sequencingSEGAtuberous sclerosis complex (TSC)zebrafish

Identifiers

PMID36238691
PMCPMC9552079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.