Evidence map›Paper›PMID 36238604›Full record

ArticleFrontiers in pediatrics2022

Genome-wide association study in patients with posterior urethral valves.

Loes F M van der Zanden, Carlo Maj, Oleg Borisov, Iris A L M van Rooij, Josine S L T Quaedackers, Martijn Steffens, Luca Schierbaum, Sophia Schneider, Lea Waffenschmidt, Lambertus A L M Kiemeney and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Genetics of CAKUT.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 15 institutions in 3 countries.

Loes F M van der ZandenDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Carlo MajInstitute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany.
Oleg BorisovInstitute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany.
Iris A L M van RooijDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Josine S L T QuaedackersDepartment of Urology, University Medical Center Groningen, Groningen, Netherlands.
Martijn SteffensDepartment of Urology, Isala, Zwolle, Netherlands.
Luca SchierbaumInstitute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
Sophia SchneiderInstitute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
Lea WaffenschmidtInstitute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
Lambertus A L M KiemeneyDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Liesbeth L L de WallDivision of Pediatric Urology, Department of Urology, Radboud Institute for Molecular Life Sciences, Radboudumc Amalia Children's Hospital, Nijmegen, Netherlands.
Stefanie HeilmannInstitute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
Aybike HofmannDepartment of Pediatric Urology, Clinic St. Hedwig, University Medical Center Regensburg, Regensburg, Germany.
Jan GehlenCenter for Human Genetics, University Hospital of Marburg, Marburg, Germany.
Johannes SchumacherCenter for Human Genetics, University Hospital of Marburg, Marburg, Germany.
Maria SzczepanskaDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.
Katarzyna Taranta-JanuszDepartment of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland.
Pawel KrollNeurourology Unit, Pediatric Surgery and Urology Clinic, Poznań, Poland.
Grazyna KrzemienDepartment of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Agnieszka SzmigielskaDepartment of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Michiel F SchreuderDepartment of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Radboudumc Amalia Children's Hospital, Nijmegen, Netherlands.
Stefanie WeberUniversity Children Hospital Marburg, Philipps University Marburg, Marburg, Germany.
Marcin ZaniewDepartment of Pediatrics, University of Zielona Góra, Zielona Góra, Poland.
Nel RoeleveldDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Heiko ReutterDivision of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
Wout F J FeitzDivision of Pediatric Urology, Department of Urology, Radboud Institute for Molecular Life Sciences, Radboudumc Amalia Children's Hospital, Nijmegen, Netherlands.
Alina C HilgerInstitute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.
University of Bonn · DEPhilipps University of Marburg · DERadboud University Medical Center · NLRadboud University Nijmegen · NLMedical University of Warsaw · PLUniversity Hospital Bonn · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEIsala · NLMedical University of Białystok · PLMedical University of Silesia · PLRadboud Institute for Molecular Life Sciences · NLUniversitätsklinikum Erlangen · DEUniversity Hospital Regensburg · DEUniversity Medical Center Groningen · NLUniversity of Zielona Góra · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior urethral valves (PUV), a male limited anatomical obstruction of the urethra affecting 1 in 4,000 male live births. Little is known about the genetic background of PUV. Here, we report the largest genome-wide association study (GWAS) for PUV in 4 cohorts of patients and controls. The final meta-analysis included 756 patients and 4,823 ethnicity matched controls and comprised 5,754,208 variants that were genotyped or imputed and passed quality control in all 4 cohorts. No genome-wide significant locus was identified, but 33 variants showed suggestive significance (

Indexed as

BMP7genome wide association studylower urinary tract obstructionobstructive uropathyPCDH9posterior urethral valvesSALL1

Identifiers

PMID36238604
PMCPMC9552614
OpenAlexW4297383514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.