Evidence map›Paper›PMID 36238285›Full record

ReviewFrontiers in immunology2022

Using personalized prognosis in the treatment of relapsing multiple sclerosis: A practical guide.

Bart Van Wijmeersch, Hans-Peter Hartung, Patrick Vermersch, Maura Pugliatti, Carlo Pozzilli, Nikolaos Grigoriadis, Mona Alkhawajah, Laura Airas, Ralf Linker, Celia Oreja-Guevara

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 11 countries.

Bart Van WijmeerschUniversitair Multiple Sclerosis (MS) Centrum, Hasselt-Pelt, Belgium.
Hans-Peter HartungDepartment of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Patrick VermerschUniversity Lille, Inserm U1172 LilNCog, Centre Hospitalier Universitaire (CHU) Lille, Fédératif Hospitalo-Universitaire (FHU) Precise, Lille, France.
Maura PugliattiDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Carlo PozzilliDepartment of Human Neuroscience, Sapienza University, Rome, Italy.
Nikolaos GrigoriadisB' Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Mona AlkhawajahNeuroscience Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Laura AirasTurku University Hospital and University of Turku, Turku, Finland.
Ralf LinkerDepartment of Neurology, University Hospital Regensburg, Regensburg, Germany.
Celia Oreja-GuevaraDepartment of Neurology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Cliínico San Carlos (IDISSC), Madrid, Spain.
Aristotle University of Thessaloniki · GRCentre Hospitalier Universitaire de Lille · FRKing Faisal Specialist Hospital & Research Centre · SAMultiple Sclerosis Foundation · USPalacký University Olomouc · CZSapienza University of Rome · ITTurku University Hospital · FIUniversidad Complutense de Madrid · ESUniversity Hospital Regensburg · DEUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical course of multiple sclerosis (MS) is highly variable among patients, thus creating important challenges for the neurologist to appropriately treat and monitor patient progress. Despite some patients having apparently similar symptom severity at MS disease onset, their prognoses may differ greatly. To this end, we believe that a proactive disposition on the part of the neurologist to identify prognostic "red flags" early in the disease course can lead to much better long-term outcomes for the patient in terms of reduced disability and improved quality of life. Here, we present a prognosis tool in the form of a checklist of clinical, imaging and biomarker parameters which, based on consensus in the literature and on our own clinical experiences, we have established to be associated with poorer or improved clinical outcomes. The neurologist is encouraged to use this tool to identify the presence or absence of specific variables in individual patients at disease onset and thereby implement sufficiently effective treatment strategies that appropriately address the likely prognosis for each patient.

Indexed as

Multiple SclerosisBiomarkersHumansMagnetic Resonance ImagingPrognosisQuality of LifeRecurrenceBiomarkersbiomarkersclinical parametersevoked potentialsmagnetic resonance imaging (MRI)multiple sclerosisoptical coherence tomographyprognosistreatment

Identifiers

PMID36238285
PMCPMC9551305
OpenAlexW4297312185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.