Evidence map›Paper›PMID 36238204›Full record

ArticleDevelopment and psychopathology2021

Trajectory of emotion dysregulation in positive and negative affect across childhood predicts adolescent emotion dysregulation and overall functioning.

Alecia C Vogel, Rebecca Tillman, Nourhan M El-Sayed, Joshua J Jackson, Susan B Perlman, Deanna M Barch, Joan L Luby

Open access · greenAbstract read
In one paragraph

Article in Development and psychopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Bidirectional association between irritability and executive function in youth from late childhood to early adolescence: Between- and within-person effects.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
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  14. Review: Defining Positive Emotion Dysregulation: Integrating Temperamental and Clinical Perspectives.Journal of the American Academy of Child and Adolescent Psychiatry · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alecia C VogelDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St Louis, MO, USA.ORCID 0000-0001-8708-0389
Rebecca TillmanDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St Louis, MO, USA.
Nourhan M El-SayedDepartment of Psychological and Brain Sciences, Washington University in St. Louis, MO, USA.
Joshua J JacksonDepartment of Psychological and Brain Sciences, Washington University in St. Louis, MO, USA.
Susan B PerlmanDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St Louis, MO, USA.
Deanna M BarchDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St Louis, MO, USA.
Joan L LubyDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St Louis, MO, USA.
Washington University in St. Louis · US

Funding

NEUROIMAGING IN EARLY ONSET DEPRESSION: LONGITUDINAL ASSESSMENT OF BRAIN CHANGESR01MH090786 · NIMH · WASHINGTON UNIVERSITY · PI GILBERT, KIRSTEN, WHALEN, DIANA J · 2010 to 2025
$10.4M
Validation of Preschool Depressive SyndromeR01MH064769 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2003 to 2012
$7.7M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
NIMH NIH HHS R01 MH064769NIMH NIH HHS R01 MH090786NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

Emotion dysregulation is cross-diagnostic and impairing. Most research has focused on dysregulated expressions of negative affect, often measured as irritability, which is associated with multiple forms of psychopathology and predicts negative outcomes. However, the Research Domain Criteria (RDoC) include both negative and positive valence systems. Emerging evidence suggests that dysregulated expressions of positive affect, or excitability, in early childhood predict later psychopathology and impairment above and beyond irritability. Typically, irritability declines from early through middle childhood; however, the developmental trajectory of excitability is unknown. The impact of excitability across childhood on later emotion dysregulation is also yet unknown. In a well-characterized, longitudinal sample of 129 children studied from ages 3 to 5.11 years through 14 to 19 years, enriched for early depression and disruptive symptoms, we assessed the trajectory of irritability and excitability using multilevel modeling and how components of these trajectories impact later emotion dysregulation. While irritability declines across childhood, excitability remains remarkably stable both within and across the group. Overall levels of excitability (excitability intercept) predict later emotion dysregulation as measured by parent and self-report and predict decreased functional magnetic resonance imaging activity in cognitive emotion regulation regions during an emotion regulation task. Irritability was not related to any dysregulation outcome above and beyond excitability.

Indexed as

Emotional RegulationMental DisordersAdolescentChildChild, PreschoolEmotionsHumansIrritable MoodMagnetic Resonance ImagingPsychopathologyemotion labilityexcitabilityfMRIirritabilityneuroimaging

Identifiers

PMID36238204
PMCPMC9555228
OpenAlexW4200626193

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.