Evidence map›Paper›PMID 36238190›Full record

ArticleTranslational neuroscience2022

The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression.

Henrik Dam, Jens O D Buch, Annelaura B Nielsen, Pia Weikop, Martin B Jørgensen

Abstract read
In one paragraph

Article in Translational neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reduced Gene Dosage of the Psychiatric Risk GeneInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Henrik DamMental Health Center Copenhagen, University Hospital of Copenhagen, Edel Sauntes Alle 10, 2100 Copenhagen O, Denmark.
Jens O D BuchMental Health Center Copenhagen, University Hospital of Copenhagen, Edel Sauntes Alle 10, 2100 Copenhagen O, Denmark.
Annelaura B NielsenNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Pia WeikopCenter for Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Martin B JørgensenMental Health Center Copenhagen, University Hospital of Copenhagen, Edel Sauntes Alle 10, 2100 Copenhagen O, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The CACNA1C protein is a L-type calcium channel, which influence affective disorders. Purpose: The purpose of the present study was to examine the possible association between the different genotypes of rs100677 CACNA1C gene and anxiety and other clinical symptoms in patients with unipolar depression. Patients and controls: A total of 754 patients and 708 controls from the Danish Psychiatric Biobank participated. Results: A significant correlation was found between anxiety and the A allele. It was further found that patients with the A allele more often were treated with electroconvulsive therapy and patients with the AA phenotype had the highest age. Limitations: The only information about controls was their sex and that they were recruited from the blood bank. Two types of inclusion criteria were used. The clinical data were not complete for all patients.

Indexed as

anxietyCACNA1CdepressionECTfirst admissionrs1006737

Identifiers

PMID36238190
PMCPMC9510822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.