Evidence map›Paper›PMID 36237989›Full record

ArticleInternational journal of medical sciences2022

Atranorin driven by nano materials SPION lead to ferroptosis of gastric cancer stem cells by weakening the mRNA 5-hydroxymethylcytidine modification of the Xc-/GPX4 axis and its expression.

Zhentian Ni, Xiaoli Nie, Hairong Zhang, Lingquan Wang, Zixiang Geng, Xiling Du, Haiyang Qian, Wentao Liu, Te Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. The role of metal ions iron, copper, and zinc in the immune microenvironment of gastric cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  3. Review
  4. Targeting ferroptosis inInternational journal of oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Zhentian NiDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiaoli NieShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China.
Hairong ZhangDepartment of Imaging, Dahua Hospital, Xuhui District, Shanghai 200237, China.
Lingquan WangDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zixiang GengDepartment of Acupuncture, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200086, China.
Xiling DuSchool of Life Science and Technology, Tongji University, Shanghai 200092, China.
Haiyang QianDepartment of Imaging, Dahua Hospital, Xuhui District, Shanghai 200237, China.
Wentao LiuDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Te LiuShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China.
Dahua Hospital · CNRuijin Hospital · CNShanghai University of Traditional Chinese Medicine · CNShanghai Jiao Tong University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is a highly malignant tumor. Gastric cancer stem cells (GCSCs) are the main causes of drug resistance, metastasis, recurrence, and poor prognosis. As a secondary metabolite of lichen, Atranorin has a variety of biological effects, such as antibacterial, anti-inflammatory, analgesic, and wound healing; however, its killing effect on GCSCs has not been reported. In this study, we constructed Atranorin complexes comprising superparamagnetic iron oxide nanoparticles (SPION) (Atranorin@SPION).

Indexed as

DioxygenasesFerroptosisStomach Neoplasms3' Untranslated RegionsAmino Acid Transport System X-AGAnalgesicsAnti-Bacterial AgentsAnti-Inflammatory AgentsCell Line, TumorCystineCytidineGene Expression Regulation, NeoplasticHumansHydroxybenzoatesMagnetic Iron Oxide NanoparticlesNeoplastic Stem Cells3' Untranslated Regions5-hydroxymethylcytidineAmino Acid Transport System X-AGAnalgesicsAnti-Bacterial AgentsAnti-Inflammatory AgentsatranorinCystineCytidineDioxygenasesHydroxybenzoatesPhospholipid Hydroperoxide Glutathione Peroxidase5-hydroxymethylcytidineAtranorinFerroptosisgastric cancer stem cell (GCSCs)superparamagnetic iron oxide nanoparticle (SPION)Xc-/GPX4 axis

Identifiers

PMID36237989
PMCPMC9553860
OpenAlexW4306248014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.