SynthesisFrontiers in cardiovascular medicine2022
Sleep duration and risk of cardio-cerebrovascular disease: A dose-response meta-analysis of cohort studies comprising 3.8 million participants.
Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Nighttime sleep duration and the prevalence of hyperuricemia: a systematic review and network meta-analysis.Frontiers in neuroscience · 2025Pooled it
- Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.PLoS medicine · 2026Article
- Prevalence and Determinants of Poor Sleep Quality Among Patients with Established Coronary Heart Disease in Kazakhstan: A Multi-Center Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Latent pain class identification, longitudinal transitions, and machine learning prediction of incident low back pain in middle-aged and older Chinese adults.BMC medical informatics and decision making · 2026Article
- Modifiable lifestyle factors and sudden cardiac death: mechanisms, evidence, and prevention strategies.Frontiers in cardiovascular medicine · 2026Review
- The Influence of Optimal Sleep Onset Time and Duration on Risk of Stroke: A Community-Based, Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Machine learning-based risk factor analysis and prediction model construction for mortality in chronic heart failure.Journal of global health · 2025Article
- Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women's health cohort.Biology of sex differences · 2025Article
- Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health: A Scientific Statement From the American Heart Association.Circulation. Cardiovascular quality and outcomes · 2025Review
- Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress.Journal of cardiothoracic surgery · 2025Review
- Association between physical activity and chronic disease multimorbidity patterns in Chinese middle-aged and older adults.Frontiers in medicine · 2025Article
- Article
- Fatigue and fallibility: the perils of prolonged shifts for neonatologists.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Sleep duration, hypnotic drug use, and risk factors: cross- sectional study.Scientific reports · 2023Article
- The link between sleep duration and stroke risk.Brain circulationArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The effect of extreme sleep duration on the risk of cardiovascular and cerebrovascular diseases (CCDs) remains debatable. The pathology of CCDs is consistent in some respects (e.g., vascular factors), suggesting that there may be an overlapping range of sleep duration associated with a low risk of both diseases We aimed to quantify the dose-response relationship between sleep duration and CCDs. Study objective: To explore whether there is an optimal sleep duration (SD) in reducing the risk of CCDs. Methods: PubMed and EMBASE were searched until June 24, 2022 to include cohort studies that investigated the longitudinal relationships of SD with incident CCDs, including stroke and coronary heart disease (CHD). The robusterror meta-regression model (REMR model) was conducted to depict the dose-response relationships based on multivariate-adjusted risk estimates. Results: A total of 71 cohorts with 3.8 million participants were included for meta-analysis, including 57 for cardiovascular diseases (CVD) and 29 for cerebrovascular disease. A significant U-shaped relationship was revealed of nighttime sleep duration with either cardiovascular or cerebrovascular disease. The nighttime sleep duration associated with a lower risk of CVD was situated within 4.3-10.3 h, with the risk hitting bottom at roughly 7.5 h per night ( Conclusion: Rational sleep duration (7.5 h/night) is associated with a reduced risk of cardio-cerebrovascular disease for adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.