Evidence map›Paper›PMID 36237764›Full record

ReviewCureus2022

The Role of Diet and Gut Microbiome in Multiple Sclerosis.

Maleesha Jayasinghe, Omesh Prathiraja, Abdul Mueez Alam Kayani, Rahul Jena, Dilushini Caldera, Minollie Suzanne Silva, Malay Singhal, Jimmy Pierre

Open access · diamondAbstract readReview
In one paragraph

Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Maleesha JayasingheMedicine, Nanjing Medical University, Nanjing, CHN.
Omesh PrathirajaMedicine and Surgery, Nanjing Medical University, Nanjing, CHN.
Abdul Mueez Alam KayaniMedicine and Surgery, Allama Iqbal Medical College, Lahore, PAK.
Rahul JenaMedicine, Bharati Vidyapeeth Medical College/Bharati Hospital, Pune, IND.
Dilushini CalderaInternal Medicine, Nanjing Medical University, Nanjing, CHN.
Minollie Suzanne SilvaMedicine and Surgery, Nanjing Medical University, Nanjing, CHN.
Malay SinghalInternal Medicine, Mahatma Gandhi Memorial Medical College, Indore, IND.
Jimmy PierreInternal Medicine, Nanjing Medical University, Nanjing, CHN.
Bharati Vidyapeeth Deemed University · INNanjing Medical University · CNAllama Iqbal Medical College · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic demyelinating condition of the central nervous system (CNS) characterized by immune-mediated damage to the myelin sheath of nerve cells. Genetic and environmental factors are believed to play a significant role. Unfortunately, the knowledge of therapeutic modalities in MS remains very limited, necessitating the need for novel therapeutic strategies. In the previous decade, there has been an influx of studies on the gut microbiome and its link to various neurological conditions, including MS. Various diets may have favorable effects on the gut microflora and may significantly alter the progression and outcomes of MS. Thus, identifying the merits of various diets and modulating them according to the specific nutritional requirements of MS patients can go a long way toward slowing the progression of the disease. Nutritional interventions and the use of the gut microbiome as diagnostic and therapeutic modalities open a host of new possibilities regarding the disease. In this review, we investigate the role of diet and the gut microbiome in the progression of MS. The functions of the gut-brain axis, antioxidants, vitamins, obesity, and various diets are also covered in this article.

Indexed as

demyelinating dieasesdietfecal microbiota transplantation (fmt)gut-brain axisintermittent fastingketogenic dietmicrobiotamind dietmultiple sclerosisobesity

Identifiers

PMID36237764
PMCPMC9548326
OpenAlexW4295138623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.