ArticleCureus2022
Hyperpigmentation as a Primary Symptom of Vitamin B12 Deficiency: A Case Report.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Skin Hyperpigmentation: An Under-Recognized Dermatological Clue to Vitamin B12 Deficiency.Clinical case reports · 2026Article
- Skin Hyperpigmentation as Initial Manifestation of Vitamin BCase reports in medicine · 2026Article
- Pernicious Anemia: A Rare Case of Vitamin B12 Deficiency With Hyperpigmentation and Pancytopenia.Case reports in medicine · 2026Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presentation of vitamin B12 deficiency varies from being asymptomatic to affecting multiple organ systems. In addition, several systemic diseases can be associated with generalized weakness and hyperpigmentation. However, vitamin B12 deficiency rarely presents with hyperpigmentation as an initial symptom. We present a rare case of a 22-year-old college student who presented with hyperpigmentation as the only physical manifestation of early vitamin B12 deficiency. This case underlines the need to rule out vitamin B12 deficiency when clinicians encounter hyperpigmentation as a solo presentation and also emphasizes the significance of early treatment in preventing the irreversible neurological manifestations of vitamin B12 deficiency.
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