Evidence map›Paper›PMID 36237628›Full record

ArticleFrontiers in neurology2022

Natural history of carotid artery free-floating thrombus-A single center, consecutive cohort analysis.

Mandy D Müller, Nikolaos Raptis, Pasquale Mordasini, Werner Z'Graggen, Andreas Raabe, Philippe Schucht, Mirjam R Heldner, David Bervini

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Angioscopy Visualized a Residual Free-Floating Thrombus in Mild Carotid Artery Stenosis Following Acute MCA Occlusion: A Case Report.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mandy D MüllerDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Nikolaos RaptisDepartment of Neurology, University Hospital Basel, Basel, Switzerland.
Pasquale MordasiniDepartment of Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Werner Z'GraggenDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Andreas RaabeDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Philippe SchuchtDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Mirjam R HeldnerDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
David BerviniDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
University of Bern · CHUniversity Hospital of Bern · CHUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Carotid free-floating thrombus (CFFT) is a rare cause of stroke and is thought to be associated with a high risk of recurrent cerebrovascular ischaemic events. The existing data on the natural history and optimal treatment modalities of CFFT is scanty and no clear recommendations exist. Objective: A retrospective analysis, single-center cohort of consecutive patients diagnosed with CFFT was conducted, investigating the risk for recurrent cerebrovascular ischaemic events. Methods: We performed a single-center retrospective analysis including all patients presenting at our tertiary center between January 2005 and December 2020 with symptoms consistent with ischaemic stroke and/or transient ischaemic attack. Digital subtraction angiography (DSA), computed tomography angiography (CTA) or magnetic resonance angiography (MRA) were used to diagnose CFFT. In all included patients, CFFT was confirmed with a second imaging modality. CFFT was defined on imaging as a defect in contrast filling extending into the carotid lumen. We gathered information on vascular risk factors, diagnosis and follow-up methods, modality of treatment and neurological outcome. A survival analysis was performed, assessing the risk for recurrent cerebrovascular events. Results: In total, Conclusion: The risk of recurrent ischaemic events in patients with CFFT is high, especially in the first week after diagnosis. Prospective studies are needed to further investigate the optimal management of these patients.

Indexed as

carotid endarterectomycarotid free-floating thrombuscarotid thromboembolismcarotid thromboendarterectomystroke risk

Identifiers

PMID36237628
PMCPMC9553207
OpenAlexW4297312240

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.