ArticleCurrent neuropharmacology2024
Central Sensitization and Pain: Pathophysiologic and Clinical Insights.
Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- CSI and Musculoskeletal Pain: Clinical Validity and Neurophysiological Implications.Current pain and headache reports · 2025Pooled it
- Efficacy of Erector Spinae Plane Block on Analgesic Outcomes in Patients Undergoing Metabolic Surgery: A Meta-Analysis of Randomized Controlled Trials.Obesity surgery · 2025Pooled it
- Behavioral speech therapy intervention can improve the postoperative pain and performance status of lung cancer patients undergoing thoracoscopic surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Early Percutaneous Cryoneurolysis for Pain Control After Rib Fracture for Older Patients: A Prospective Randomized Clinical Trial.Journal of the American College of Surgeons · 2026Trial
- The Pericapsular Nerve Group (PENG) block in physical and rehabilitation medicine: an opinion paper.Journal of rehabilitation medicine · 2026Article
- Multidimensional Recovery Trajectories Throughout Breast Cancer Treatment and Survivorship: A Prospective Longitudinal Study.Current oncology (Toronto, Ont.) · 2026Article
- Central Sensitization and Pain Catastrophizing Are More Strongly Associated with Health-Related Quality of Life than Bioelectrical Impedance Analysis-Derived Body-Composition Measures in Patients with Chronic Low Back Pain.Diagnostics (Basel, Switzerland) · 2026Article
- Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Molecular biomedicine · 2026Review
- Neurobiological and Neuroimmune Mechanisms Linking Chronic Pain, Sleep Disturbances and Mental Health Disorders.International journal of molecular sciences · 2026Review
- Proximal Hamstring-Related Sciatic Nerve Entrapment Presenting as Recurrent Hamstring Strain in a Professional Footballer: A Case Report.Journal of orthopaedic case reports · 2026Article
- Immediate Effects of Fascial Manipulation on Pain in Patients with Myofascial Densification and Central Sensitization: A Case Series.International journal of therapeutic massage & bodywork · 2026Article
- Activating Transcription Factor 3 in Pain: A Molecular Regulator and Emerging Biomarker.Genes · 2026Review
- Can Chronic Pain Accelerate Chronic Kidney Disease? Is Pain a Disease Modifier Rather than a Symptom?Life (Basel, Switzerland) · 2026Article
- Longitudinal Changes in Somatosensory Function and Their Association with Pain Trajectory Groups in a Portuguese Cancer Center Cohort.Biomedicines · 2026Article
- Meditations on Methodological Issues in Clinical Investigations of "Central Sensitization" (Jonah XII).Journal of clinical medicine · 2026Article
- Personalized Prediction of Acute and Chronic Postsurgical Pain - the role of Multidomain Biosignatures, Machine Learning-Based Integration, and Standardized Outcome Definitions.Current pain and headache reports · 2026Review
- Review
- Differences in Depression and Anxiety, Quality of Life and Quality of Sleep Between Neuropathic and Nociceptive Patients with Chronic Low Back Pain: A Comparative, Multi-Center, Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Not All Microbiomes Reflect Chronic Pain: Evidence from the Urinary Tract in a Case-Control Study.Journal of clinical medicine · 2026Article
- Predictive Value of Anxiety State During Acute Herpes Zoster for the Development of Postherpetic Neuralgia.Actas espanolas de psiquiatria · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Central sensitization is an increased responsiveness of nociceptive neurons in the central nervous system to their normal or subthreshold afferent input.
aimTo explain how the notion of central sensitization has changed our understanding of pain conditions, discuss how this knowledge can be used to improve the management of pain, and highlight knowledge gaps that future research needs to address.
methodsOverview of definitions, assessment methods, and clinical implications.
resultsHuman pain models, and functional and molecular imaging have provided converging evidence that central sensitization occurs and is clinically relevant. Measures to assess central sensitization in patients are available; however, their ability to discriminate sensitization of central from peripheral neurons is unclear. Treatments that attenuate central sensitization are available, but the limited understanding of molecular and functional mechanisms hampers the development of target-specific treatments. The origin of central sensitization in human pain conditions that are not associated with tissue damage remains unclear.
conclusionThe knowledge of central sensitization has revolutionized our neurobiological understanding of pain. Despite the limitations of clinical assessment in identifying central sensitization, it is appropriate to use the available tools to guide clinical decisions towards treatments that attenuate central sensitization. Future research that elucidates the causes, molecular and functional mechanisms of central sensitization would provide crucial progress towards the development of treatments that target specific mechanisms of central sensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.