Evidence map›Paper›PMID 36237132›Full record

ArticleCancer medicine2023

A pyroptosis-related lncRNA signature in bladder cancer.

Peng Wang, Zhiqiang Wang, Liping Zhu, Yilan Sun, Leandro Castellano, Justin Stebbing, Zhentao Yu, Ling Peng

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  6. Roles of LncRNAs in the Pathogenesis of Pulmonary Hypertension.Reviews in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Peng WangDepartment of Medical Oncology, Yidu Central Hospital of Weifang, Weifang, China.
Zhiqiang WangDepartment of Urology, Shouguang Hospital of Traditional Chinese Medicine, Shouguang, China.
Liping ZhuDepartment of Medical Oncology, Shouguang Hospital of Traditional Chinese Medicine, Shouguang, China.
Yilan SunDepartment of Respiratory Disease, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Zhejiang, China.
Leandro CastellanoDepartment of Biochemistry, School of Life Sciences, University of Sussex, Brighton, UK.
Justin StebbingDivision of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK.
Zhentao YuDepartment of Thoracic Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Ling PengDepartment of Respiratory Disease, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Zhejiang, China.ORCID 0000-0002-1359-4982
Zhejiang Provincial People's Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNImperial College London · GBNanfang Hospital · CNShougang (China) · CNUniversity of Sussex · GBYidu Central Hospital of Weifang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePyroptosis, a type of programmed cell death, is implicated in the tumorigenesis, development and migration of cancer, which can be regulated by long non-coding RNAs (lncRNAs). Our research aimed to investigate the prognostic role of pyroptosis-related lncRNAs and the relationship to the tumor immune microenvironment through bioinformatics analysis.

methodsThe clinical and RNA-sequencing data of bladder cancer patients were downloaded from The Cancer Genome Atlas (TCGA). And 412 bladder cancer subjects with clinical information were divided into training and testing cohort. And 52 reported pyroptosis-related genes were used to screen pyroptosis-related lncRNAs. A pyroptosis-related lncRNA signature was constructed based on Cox regression analyses.

resultsA 9-pyroptosis-related-lncRNA signature was identified to separate patients with bladder cancer into two groups. The prognosis of bladder cancer patients in the high-risk group was significantly inferior compared with those in the low-risk group. Risk scores were validated to develop an independent prognostic indicator based on multivariate Cox regression analysis. Receiver operating characteristic curve (ROC) analysis examined the signature on overall survival. The area under time-dependent ROC curve (AUC) at 1-, 3, and 5-years measured 0.747, 0.783, and 0.768, respectively. Analysis of the immune landscape and PD-L1 expression showed that PD-L1 is upregulated in the high-risk group. The immunocyte subtypes of the two groups were different.

conclusionA novel pyroptosis-related lncRNA signature was identified with prognostic value for bladder cancer patients. Pyroptosis-related lncRNAs have a potential role in cancer immunology and may serve as prognostic or therapeutic targets.

Indexed as

RNA, Long NoncodingUrinary Bladder NeoplasmsApoptosisB7-H1 AntigenHumansPrognosisPyroptosisTumor MicroenvironmentB7-H1 AntigenRNA, Long Noncodingbladder cancerlncRNAprognostic signaturePyroptosistumor immune microenvironment

Identifiers

PMID36237132
PMCPMC10028168
OpenAlexW4306157776

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.