ArticlePolymers2022
Grafted Microparticles Based on Glycidyl Methacrylate, Hydroxyethyl Methacrylate and Sodium Hyaluronate: Synthesis, Characterization, Adsorption and Release Studies of Metronidazole.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Nanoscale Approaches to Oro-Dental Tissue Engineering: A Review of Strategies, Composites, and Translational Challenges.International journal of nanomedicine · 2026Review
- Application of a novel thermal/pH-responsive antibacterial paeoniflorin hydrogel crosslinked with amino acids for accelerated diabetic foot ulcers healing.Materials today. Bio · 2025Article
- Advances in hybridized nanoarchitectures for improved oro-dental health.Journal of nanobiotechnology · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three types of precursor microparticles based on glycidyl methacrylate, hydroxyethyl methacrylate and one of the following three crosslinking agents (mono-, di- or triethylene glycol dimethacrylate) were prepared using the suspension polymerization technique. The precursor microparticles were subsequently used to obtain three types of hybrid microparticles. Their synthesis took place by grafting sodium hyaluronate, in a basic medium, to the epoxy groups located on the surface of the precursor microparticles. Both types of the microparticles were characterized by: FTIR spectroscopy, epoxy groups content, thermogravimetric analysis, dimensional analysis, grafting degree of sodium hyaluronate, SEM and AFM analyses, and specific parameters of porous structures (specific surface area, pore volume, porosity). The results showed that the hybrid microparticles present higher specific surface areas, higher swelling capacities as well as higher adsorption capacities of antimicrobial drugs (metronidazole). To examine the interactions between metronidazole and the precursor/hybrid microparticles the adsorption equilibrium, kinetic and thermodynamic studies were carried out. Thus, it was determined the performance of the polymer systems in order to select a polymer-drug system with a high efficiency. The release kinetics reflect that the release mechanism of metronidazole in the case of hybrid microparticles is a complex mechanism characteristic of anomalous or non-Fickian diffusion.
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Registered trials
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