Evidence map›Paper›PMID 36235908›Full record

ArticlePolymers2022

Morphological and Quantitative Evidence for Altered Mesenchymal Stem Cell Remodeling of Collagen in an Oxidative Environment-Peculiar Effect of Epigallocatechin-3-Gallate.

Regina Komsa-Penkova, Svetoslava Stoycheva, Pencho Tonchev, Galya Stavreva, Svetla Todinova, Galya Georgieva, Adelina Yordanova, Stanimir Kyurkchiev, George Altankov

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Regina Komsa-PenkovaDepartment of Biochemistry, Medical University Pleven, 5800 Pleven, Bulgaria.
Svetoslava StoychevaDepartment of Biochemistry, Medical University Pleven, 5800 Pleven, Bulgaria.
Pencho TonchevDepartment of Surgery, Medical University Pleven, 5800 Pleven, Bulgaria.ORCID 0000-0002-9213-748X
Galya StavrevaDepartment of Experimental and Clinical Pharmacology, Medical University Pleven, 5800 Pleven, Bulgaria.ORCID 0000-0002-4026-1980
Svetla TodinovaInstitute for Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1330 Sofia, Bulgaria.ORCID 0000-0001-7108-051X
Galya GeorgievaDepartment of Biochemistry, Medical University Pleven, 5800 Pleven, Bulgaria.
Adelina YordanovaTissue Bank BulGen, Str. Hristo Blagoev 25, 1330 Sofia, Bulgaria.
Stanimir KyurkchievTissue Bank BulGen, Str. Hristo Blagoev 25, 1330 Sofia, Bulgaria.
George AltankovAssociate Member of Institute for Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1330 Sofia, Bulgaria.
Medical University Pleven · BGBulgarian Academy of Sciences · BGBulgarian National Bank · BG

Funding

Medical University Pleven, Bulgaria MU-Project 16/2020 and MU-Project 14/2021Science and education for intelligence growth, within EU regional and urban development, Operational Programme Science and Education for Smart Growth G05M2OP001-1.002-0010
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are involved in the process of extracellular matrix (ECM) remodeling where collagens play a pivotal role. We recently demonstrated that the remodeling of adsorbed collagen type I might be disordered upon oxidation following its fate in the presence of human adipose-derived MSC (ADMSCs). With the present study we intended to learn more about the effect of polyphenolic antioxidant Epigallocatechin-3-gallate (EGCG), attempting to mimic the conditions of oxidative stress in vivo and its putative prevention by antioxidants. Collagen Type I was isolated from mouse tail tendon (MTC) and labelled with FITC before being oxidized according to Fe

Indexed as

adipose tissue-derived mesenchymal stem cellADMSCcollagen type IEGCGoxidationremodeling

Identifiers

PMID36235908
PMCPMC9571090
OpenAlexW4297005713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.