Evidence map›Paper›PMID 36235903›Full record

ArticlePolymers2022

Biocompatibility of 3D-Printed PLA, PEEK and PETG: Adhesion of Bone Marrow and Peritoneal Lavage Cells.

Stanislav Y Shilov, Yulia A Rozhkova, Lubov N Markova, Mikhail A Tashkinov, Ilya V Vindokurov, Vadim V Silberschmidt

Abstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  18. Advancing bovineFrontiers in bioengineering and biotechnology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stanislav Y ShilovLaboratory of Ecological Immunology, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, 614081 Perm, Russia.
Yulia A RozhkovaChemical Engineering Faculty, Perm National Research Polytechnic University, 614990 Perm, Russia.ORCID 0000-0002-3199-455X
Lubov N MarkovaLaboratory of Experimental Pharmacology, Faculty of Chemistry, Perm State National Research University, 614990 Perm, Russia.
Mikhail A TashkinovLaboratory of Mechanics of Biocompatible Materials and Devices, Perm National Research Polytechnic University, 614990 Perm, Russia.
Ilya V VindokurovLaboratory of Mechanics of Biocompatible Materials and Devices, Perm National Research Polytechnic University, 614990 Perm, Russia.ORCID 0000-0002-1885-0404
Vadim V SilberschmidtWolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leicestershire, Loughborough LE11 3TU, UK.ORCID 0000-0003-3338-3311

Funding

Mega-grants program of RF Government no. 075-15-2021-578 of May 31, 2021, hosted by Perm National Research Polytechnic University.
6 · The paper itself

Abstract

Samples in the form of cylindrical plates, additively manufactured using the fused deposition modelling (or filament freeform fabrication, FDM/FFF) technology from polylactide (PLA), polyethylene terephthalate glycol (PETG) and polyetheretherketone (PEEK), were studied in series of in-vitro experiments on the adhesion of rat bone-marrow cells and rat peritoneal cells. Methods of estimation of the absolute number of cells and polymer samples' mass change were used for the evaluation of cells adhesion, followed by the evaluation of cell-culture supernatants. The results of experiments for both types of cells demonstrated a statistically significant change in the absolute number of cells (variation from 44 to 119%) and the weight of the polymer samples (variation from 0.61 to 2.18%), depending on roughness of sample surface, controlled by a nozzle diameter of a 3D printer as well as printing layer height. It was found that more cells adhere to PLA samples with a larger nozzle diameter and layer height. For PETG samples, the results did not show a clear relationship between cell adhesion and printing parameters. For PEEK samples, on the contrary, adhesion to samples printed with a lower nozzle diameter (higher resolution) is better than to samples printed with a larger nozzle diameter (lower resolution). The difference in results for various polymers can be explained by their chemical structure.

Indexed as

3D printingbiocompatibilitybone marrowcell adhesionimplantsperitoneal cellspolyether ether ketonepolyethylene terephthalate glycolpolylactide

Identifiers

PMID36235903
PMCPMC9571806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.