Evidence map›Paper›PMID 36235818›Full record

ReviewNutrients2022

Royal Jelly: Beneficial Properties and Synergistic Effects with Chemotherapeutic Drugs with Particular Emphasis in Anticancer Strategies.

Suzy Salama, Qiyang Shou, Aida A Abd El-Wahed, Nizar Elias, Jianbo Xiao, Ahmed Swillam, Muhammad Umair, Zhiming Guo, Maria Daglia, Kai Wang and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Targeting Oxidative Stress for Disease.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Heavy Metal Concentrations of Beeswax (Apis mellifera L.) at Different Ages.Bulletin of environmental contamination and toxicology · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 6 countries.

Suzy SalamaIndigenous Knowledge and Heritage Center, Ghibaish College of Science and Technology, Ghibaish 51111, Sudan.ORCID 0000-0003-0430-1436
Qiyang ShouSecond Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Aida A Abd El-WahedDepartment of Bee Research, Plant Protection Research Institute, Agricultural Research Centre, Giza 12627, Egypt.ORCID 0000-0002-2200-3507
Nizar EliasFaculty of Medicine, University of Kalamoon, Dayr Atiyah P.O. Box 222, Syria.
Jianbo XiaoNutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Sciences, Universidade de Vigo, 32004 Ourense, Spain.ORCID 0000-0003-3311-770X
Ahmed SwillamFaculty of Pharmacy, Menoufia University, Shebin El-Koom 32512, Egypt.ORCID 0000-0003-0753-3718
Muhammad UmairDepartment of Food Science and Technology, College of Chemistry and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-2035-686X
Zhiming GuoSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0001-6416-7457
Maria DagliaDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-4870-7713
Kai WangInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.ORCID 0000-0003-0553-5293
Shaden A M KhalifaDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91 Stockholm, Sweden.
Hesham R El-SeediInternational Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
Jiangsu University · CNAgricultural Research Center · EGChinese Academy of Agricultural Sciences · CNMenoufia University · EGShenzhen University · CNStockholm University · SEUniversidade de Vigo · ESUniversity of Kalamoon · SYZhejiang Chinese Medical University · CN

Funding

National Natural Science Foundation of China 81873047
6 · The paper itself

Abstract

Cancer is one of the major causes of death globally. Currently, various methods are used to treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious adverse effects. A healthy lifestyle, especially a nutritional diet, plays a critical role in the treatment and prevention of many disorders, including cancer. The above notion, plus the trend in going back to nature, encourages consumers and the food industry to invest more in food products and to find potential candidates that can maintain human health. One of these agents, and a very notable food agent, is royal jelly (RJ), known to be produced by the hypopharyngeal and mandibular salivary glands of young nurse honeybees. RJ contains bioactive substances, such as carbohydrates, protein, lipids, peptides, mineral salts and polyphenols which contribute to the appreciated biological and pharmacological activities. Antioxidant, anticancer, anti-inflammatory, antidiabetic, and antibacterial impacts are among the well-recognized benefits. The combination of RJ or its constituents with anticancer drugs has synergistic effects on cancer disorders, enhancing the drug's effectiveness or reducing its side effects. The purpose of the present review is to emphasize the possible interactions between chemotherapy and RJ, or its components, in treating cancer illnesses.

Indexed as

Antineoplastic AgentsDrug-Related Side Effects and Adverse ReactionsNeoplasmsAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntioxidantsBeesCarbohydratesFatty AcidsHumansHypoglycemic AgentsMineralsRoyal JellySaltsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsCarbohydratesFatty AcidsHypoglycemic AgentsMineralsRoyal JellySaltsanticancer drugscancerroyal jellysynergistic effect

Identifiers

PMID36235818
PMCPMC9573021
OpenAlexW4303961883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.