Evidence map›Paper›PMID 36235752›Full record

ArticleNutrients2022

A Healthful Plant-Based Diet Is Associated with Lower Odds of Nonalcoholic Fatty Liver Disease.

Xiude Li, Zhaohong Peng, Meiling Li, Xueke Zeng, Haowei Li, Yu Zhu, Hui Chen, Anla Hu, Qihong Zhao, Zhuang Zhang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

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  4. Nutritional and Fasting Strategies for the Management of MASLD/MASH: An Integrative Review.JGH open : an open access journal of gastroenterology and hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Xiude LiDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Zhaohong PengDepartment of Interventional Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
Meiling LiDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Xueke ZengDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Haowei LiDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Yu ZhuDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Hui ChenDepartment of Big Data and Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Anla HuDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Qihong ZhaoDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.ORCID 0000-0002-7894-5691
Zhuang ZhangDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.
Hua WangDepartment of Oncology, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei 230032, China.ORCID 0000-0002-2605-5697
Changzheng YuanDepartment of Big Data and Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Wanshui YangDepartment of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China.ORCID 0000-0002-7365-2689
Anhui Medical University · CNMinistry of Education of the People's Republic of China · CNZhejiang University · CN

Funding

Anhui Provincial Education Department gxyqZD2021099Anhui Provincial Natural Science Foundation 2008085MH262Anhui Provincial Natural Science Foundation 2108085QH357grants from Anhui Medical University 2021xkjT007grants from Anhui Medical University XJ201935National Natural Science Foundation of China 82073651
6 · The paper itself

Abstract

There is little evidence for the associations of the overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI) with the odds of nonalcoholic fatty liver disease (NAFLD). We present a nationwide cross-sectional study among US adults aged 18 years or older. Diet was assessed by 24-h recalls. Overall PDI, hPDI, and uPDI were constructed based on 18 food groups. NAFLD was defined based on controlled attenuation parameter derived via transient elastography (TE) in the absence of other causes of chronic liver disease. Among 3900 participants with eligible TE examination, 1686 were diagnosed with NAFLD. The overall PDI was not associated with NAFLD prevalence (comparing extreme tertiles of PDI score OR = 1.03, 95% CI 0.76, 1.38, ptrend = 0.609). However, hPDI was inversely (OR = 0.50, 95% CI 0.35, 0.72, ptrend < 0.001), while uPDI was positively associated with odds of NAFLD (OR = 1.37, 95% CI 0.93, 2.02, ptrend = 0.009) in the multivariable-adjusted models without body mass index (BMI). After further adjustment for BMI, only the association of hPDI with NAFLD remained statistically significant (OR = 0.64, 95% CI 0.46, 0.87, ptrend = 0.006). Such inverse association appeared stronger in non-Hispanic whites, but not in other racial/ethnic groups (pinteraction = 0.009). Our findings suggest that a plant-based diet rich in healthy plant foods might be associated with lower odds of NAFLD, particularly among US non-Hispanic whites. Clinical trials and cohort studies to validate our findings are needed.

Indexed as

Non-alcoholic Fatty Liver DiseaseAdultCross-Sectional StudiesDietDiet, HealthyDiet, VegetarianHumansPlantsbody mass indexcontrolled attenuation parameternonalcoholic fatty liver diseasesplant-based diet

Identifiers

PMID36235752
PMCPMC9572274
OpenAlexW4303962007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.