Evidence map›Paper›PMID 36235710›Full record

ArticleNutrients2022

Maternal Low-Protein Diet during Puberty and Adulthood Aggravates Lipid Metabolism of Their Offspring Fed a High-Fat Diet in Mice.

Xiaohua Huang, Yong Zhuo, Dandan Jiang, Yingguo Zhu, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Lun Hua, Yuanfeng Zou and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Xiaohua HuangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-8348-4199
Dandan JiangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Yingguo ZhuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Zhengfeng FangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Yan LinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0001-6339-9512
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-4415-8542
Lun HuaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Yuanfeng ZouCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-3116-1478
Chao HuangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Lixia LiCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-2772-264X
De WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Bin FengAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0001-6258-2729
Sichuan Agricultural University · CN

Funding

Fok Ying Tung Foundation 171019Young Scientist Project of National Key R&D Program SQ2022YFD1300010
6 · The paper itself

Abstract

A maternal low-protein (LP) diet during gestation and/or lactation results in metabolic syndrome in their offspring. Here, we investigated the effect of maternal LP diet during puberty and adulthood on the metabolic homeostasis of glucose and lipids in offspring. Female mice were fed with normal-protein (NP) diet or a LP diet for 11 weeks. Male offspring were then fed with a high-fat diet (NP-HFD and LP-HFD groups) or standard chow diet (NP-Chow and LP-Chow groups) for 4 months. Results showed that maternal LP diet during puberty and adulthood did not alter the insulin sensitivity and hepatic lipid homeostasis of their offspring under chow diet, but aggravated insulin resistance, hepatic steatosis, and hypercholesterolemia of offspring in response to a post-weaning HFD. Accordingly, transcriptomics study with offspring's liver indicated that several genes related to glucose and lipid metabolism, including lipoprotein lipase (

Indexed as

Fatty LiverInsulin ResistancePrenatal Exposure Delayed EffectsAnimalsApoproteinsCholesterol 7-alpha-HydroxylaseCoenzyme ADiet, High-FatDiet, Protein-RestrictedFemaleFibroblast Growth Factor 1GlucoseLigasesLipid MetabolismLipidsLipoprotein LipaseApoproteinsCholesterol 7-alpha-HydroxylaseCoenzyme AFibroblast Growth Factor 1GlucoseLigasesLipidsLipoprotein Lipasecholesterolhepatic steatosisinsulin sensitivitylow-protein dietmaternal dietoffspring

Identifiers

PMID36235710
PMCPMC9570549
OpenAlexW4297988888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.