ArticleNutrients2022
Insights into Modifiable Risk Factors of Infertility: A Mendelian Randomization Study.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Review of Mendelian randomization studies on common male-specific diseases.Frontiers in endocrinology · 2025Pooled it
- The Association between Circulating Lipids and Female Infertility Risk: A Univariable and Multivariable Mendelian Randomization Analysis.Nutrients · 2023Pooled it
- Changes in ambient environmental conditions correspond to variations inFrontiers in endocrinology · 2026Article
- Dietary supplementation of male mice with inorganic, organic or nanoparticle selenium preparations: evidence supporting a putative gut-thyroid-male fertility axis.Redox report : communications in free radical research · 2025Article
- Association between high-density lipoprotein-related inflammation index and female infertility in US reproductive-aged women: insights from NHANES 2013-2020.BMC women's health · 2025Article
- Education, socioeconomic status, leisure sedentary behaviors and female infertility: mendelian randomization study.BMC women's health · 2025Article
- Association between vitamin B2 intake and female infertility: a cross-sectional study.Scientific reports · 2025Article
- The causal effects of systemic antioxidant capacity on male infertility: A two-sample mendelian randomization analysis.Scientific reports · 2025Article
- Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study.BMC pregnancy and childbirth · 2025Article
- Epidemiological characteristics of infertility, 1990-2021, and 15-year forecasts: an analysis based on the global burden of disease study 2021.Reproductive health · 2025Article
- Trends in male infertility burden in South Asia: a 30-year analysis of DALYs, prevalence, and future projections based on GBD 2021.Frontiers in reproductive health · 2025Article
- Consumption of Ultra-Processed Foods and Semen Quality in Healthy Young Men Living in Italy.Nutrients · 2024Article
- Evaluating the association of female obesity with the risk of live birth following IVF: Implications for clinical practice.The practising midwife · 2024Article
- Non-high-density to high-density lipoprotein cholesterol ratio and its association with infertility in U.S. women: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study.BMC public health · 2023Article
- Diet and Fertility Status: Relevance in Health and Disease.Nutrients · 2023Article
- Physiological Benefits of Novel Selenium Delivery via Nanoparticles.International journal of molecular sciences · 2023Review
- Application and discoveries of metabolomics and proteomics in the study of female infertility.Frontiers in endocrinology · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObservational studies have linked lifestyle, diet, obesity, and biochemical measures with infertility. Whether this association is causal is unclear. We sought to identify the causal relationship between modifiable risk factors with infertility.
methodsUsing single-nucleotide polymorphisms (SNPs) as a genetic instrument variable, we carried out a two-sample Mendelian randomization (MR) analysis to estimate the causal effects for 22 modifiable risk factors on female infertility (6481 cases; 75,450 participants) and male infertility (680 cases; 73,479 participants).
resultsThe results of the study showed that BMI (OR: 1.24, 95% CI (1.09, 1.40)), body fat percentage (OR: 1.73, 95% CI (1.13, 2.64)), and alcohol consumption (OR: 6.57,95% CI (1.2, 36.14)) are associated with a higher risk of male infertility, and total fatty acids (OR: 1.16, 95% CI (1.03, 1.30), omega-6 fatty acids (OR: 1.14, 95% CI (1.00, 1.27)), and monounsaturated fatty acids (OR: 1.14, 95% CI (1.03, 1.28) are associated with a higher risk of infertility in women. We observed that higher education (OR: 0.77, 95% CI (0.64, 0.92)) was a protective factor for female infertility.
conclusionsBMI, body fat percentage, and alcohol consumption are risk factors for male infertility; total fatty acids, omega-6 fatty acids, and monounsaturated fatty acids are risk factors for female infertility, and education is a protective factor for female infertility.
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