ArticleNutrients2022
Circulating Levels of Short-Chain Fatty Acids during Pregnancy and Infant Neurodevelopment.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- Gut-Derived Metabolic Imbalance in Autism Spectrum Disorder: Toward the Concept of a Metabolic Subtype.Nutrients · 2026Review
- Characteristics and functions of the gut microbiome in monozygotic twins with autism spectrum disorders of varying severity.World journal of psychiatry · 2026Article
- The effects of maternal dietary fiber and short-chain fatty acids on the health of offspring: a mini review.Frontiers in nutrition · 2026Review
- Impact of maternal microbiota imbalance during pregnancy on fetal cerebral neurodevelopment: Is there a link to certain autistic disorders?Brain, behavior, & immunity - health · 2025Review
- Relationship of SCFAs to Maternal and Child Anthropometric Measurements.International journal of molecular sciences · 2025Article
- Cross-generational mechanisms of maternal gut microbiota in modulating offspring autism spectrum disorder risk: from the gut-brain axis to translational challenges in precision interventions.Frontiers in aging neuroscience · 2025Review
- Neonatal gut microbiota stratification and identification of SCFA-associated microbial subgroups using unsupervised clustering and machine learning classification.Frontiers in microbiology · 2025Article
- MICROBIOME: The trials and errors of developing an experimental model to study the impact of maternal gut microbiome disruption on perinatal asphyxia.Reproduction & fertility · 2024Article
- Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy.World journal of hepatology · 2024Article
- Microbiota-derived short chain fatty acids in pediatric health and diseases: from gut development to neuroprotection.Frontiers in microbiology · 2024Review
- Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis.CNS neuroscience & therapeutics · 2024Review
- Programming Factors of Neonatal Intestinal Dysbiosis as a Cause of Disease.International journal of molecular sciences · 2023Review
- Expression and clinical significance of short-chain fatty acids in pregnancy complications.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundShort-chain fatty acids (SCFA) play a key role in the gut microbiota-brain crosstalk regulating the main neurodevelopmental processes during pregnancy. The aim of this study is to investigate the longitudinal relationship between prenatal levels of the main SCFAs in maternal serum and infant cognitive development and temperament on day 40 postpartum after adjusting for several pre-, peri- and post-natal confounders.
methodsA sample of 357 healthy mother-infant pairs were followed from the beginning of pregnancy to 40 days after birth. Serum SCFA concentrations were assessed in the first and third trimester of pregnancy by LC-MS/MS; and socio-demographic, nutritional, and psychological variables were collected. At 40 days, the Bayley Scales of Infant Development-III and the Early Infancy Temperament Questionnaire were administered.
resultsLower serum levels of acetic, butyric and isobutyric acid, mainly during the first trimester, were related to better language and psychomotor development and, in the case of butyric acid, better intensity behavior in infants. Medium levels of propionic acid were related to better scores for development, mood and temperament.
conclusionsThese findings suggest that in a community sample of healthy pregnant women from a Mediterranean region of northern Spain, lower serum levels of SCFAs, especially in the first trimester of pregnancy, seem to be related to better infant neurodevelopment.
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