Evidence map›Paper›PMID 36235599›Full record

ArticleNutrients2022

Quantity and Source of Protein during Complementary Feeding and Infant Growth: Evidence from a Population Facing Double Burden of Malnutrition.

Kulnipa Kittisakmontri, Julie Lanigan, Jonathan C K Wells, Suphara Manowong, Sujitra Kaewarree, Mary Fewtrell

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kulnipa KittisakmontriChildhood Nutrition Research Centre, Department of Population, Policy and Practice, Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0002-9612-5048
Julie LaniganChildhood Nutrition Research Centre, Department of Population, Policy and Practice, Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Jonathan C K WellsChildhood Nutrition Research Centre, Department of Population, Policy and Practice, Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.ORCID 0000-0003-0411-8025
Suphara ManowongDepartment of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Sujitra KaewarreeDepartment of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Mary FewtrellChildhood Nutrition Research Centre, Department of Population, Policy and Practice, Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
University College London · GBChiang Mai University · TH

Funding

the NIHR Great Ormond Street Hospital Biomedical Research Centre. none
6 · The paper itself

Abstract

backgroundWhile high protein intake during infancy may increase obesity risk, low qualities and quantities of protein contribute to undernutrition. This study aimed to investigate the impact of the amount and source of protein on infant growth during complementary feeding (CF) in a country where under- and overnutrition co-exist as the so-called the double burden of malnutrition.

methodsA multicenter, prospective cohort was conducted. Healthy term infants were enrolled with dietary and anthropometric assessments at 6, 9 and 12 months (M). Blood samples were collected at 12M for IGF-1, IGFBP-3 and insulin analyses.

resultsA total of 145 infants were enrolled (49.7% female). Animal source foods (ASFs) were the main protein source and showed a positive, dose-response relationship with weight-for-age, weight-for-length and BMI z-scores after adjusting for potential confounders. However, dairy protein had a greater impact on those parameters than non-dairy ASFs, while plant-based protein had no effect. These findings were supported by higher levels of IGF-1, IGFBP-3 and insulin following a higher intake of dairy protein. None of the protein sources were associated with linear growth.

conclusionsThis study showed the distinctive impact of different protein sources during CF on infant growth. A high intake of dairy protein, mainly from infant formula, had a greater impact on weight gain and growth-related hormones.

Indexed as

Dietary ProteinsInfant Nutritional Physiological PhenomenaMalnutritionHormonesHumansInfantInfant FormulaInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulinsProspective StudiesDietary ProteinsHormonesInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulinsanimal source foodscomplementary feedingdouble burden of malnutritionearly-life nutritioninfant growthinsulininsulin-like growth factor-1protein intake

Identifiers

PMID36235599
PMCPMC9572535
OpenAlexW4297238113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.