ArticleNutrients2022
Iron Depletion in Systemic and Muscle Compartments Defines a Specific Phenotype of Severe COPD in Female and Male Patients: Implications in Exercise Tolerance.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression.Frontiers in nutrition · 2023Pooled it
- Association between iron homestasis and all-cause mortality in acute pancreatitis: A retrospective MIMIC-IV database analysis.Medicine · 2025Observational
- Associations between serum levels of ferroptosis-related molecules and outcomes in stable COPD: an exploratory prospective observational study.Internal and emergency medicine · 2025Observational
- Association between iron homeostasis and prognosis in patients with chronic obstructive pulmonary disease: a retrospective analysis from MIMIC-IV database.Frontiers in medicine · 2025Article
- Review
- Iron deficiency and supplementation in heart failure.Nature reviews. Cardiology · 2024Review
- COPD: systemic proteomic profiles in frequent and infrequent exacerbators.ERJ open research · 2024Article
- Article
- Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia.Frontiers in nutrition · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We hypothesized that iron content and regulatory factors, which may be involved in exercise tolerance, are differentially expressed in systemic and muscle compartments in iron deficient severe chronic obstructive pulmonary disease (COPD) patients. In the vastus lateralis and blood of severe COPD patients with/without iron depletion, iron content and regulators, exercise capacity, and muscle function were evaluated in 40 severe COPD patients: non-iron deficiency (NID) and iron deficiency (ID) (20 patients/group). In ID compared to NID patients, exercise capacity, muscle iron and ferritin content, serum transferrin saturation, hepcidin-25, and hemojuvelin decreased, while serum transferrin and soluble transferrin receptor and muscle IRP-1 and IRP-2 increased. Among all COPD, a significant positive correlation was detected between FEV
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