Trace Element Interactions, Inflammatory Signaling, and Male Sex Implicated in Reduced Growth Following Excess Oral Iron Supplementation in Pre-Weanling Rats.

Shasta A McMillen, Eric B Nonnecke, Bo Lönnerdal

Open access · goldAbstract read

In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia.Nutrients · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shasta A McMillenDepartment of Nutrition, University of California, Davis, CA 95616, USA.ORCID 0000-0001-7373-3844

Eric B NonneckeDepartment of Nutrition, University of California, Davis, CA 95616, USA.ORCID 0000-0001-5345-2009

Bo LönnerdalDepartment of Nutrition, University of California, Davis, CA 95616, USA.

University of California, Davis · US

Funding

Albion Minerals and Balchem Corpration A18-2211

6 · The paper itself

Abstract

Iron supplements are frequently provided to infants in high-income countries despite low incidence of iron deficiency. There is growing concern regarding adverse health and development outcomes of excess iron provision in early life. Excess iron may directly damage developing organs through the formation of reactive oxygen species, alter systemic inflammatory signaling, and/or dysregulate trace mineral metabolism. To better characterize the in vivo effects of excess iron on development, we utilized a pre-weanling rat pup model. Lewis rat litters were culled to eight pups (four males and four females) and randomly assigned to daily supplementation groups receiving either vehicle control (CON; 10%

Indexed as

Iron OverloadTrace ElementsAnimalsCopperDietary SupplementsFemaleFerrous CompoundsIronMaleRatsRats, Inbred LewReactive Oxygen SpeciesSucroseZincCopperFerrous Compoundsferrous sulfateIronReactive Oxygen SpeciesSucroseTrace ElementsZincinfantsinflammationiron supplementationiron toxicityrat modeltrace mineral interactions

Identifiers

PMID36235565

DOI10.3390/nu14193913

PMCPMC9571796

OpenAlexW4296614653

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.