ArticleMolecules (Basel, Switzerland)2022
Screening and Determination of Synthetic PDE-5 Inhibitors in Adulterated Sexual Enhancement Supplements.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Phosphodiesterase Type 5 Inhibitors as Chemical Hazards in Honey and Honey-Based Products.Molecules (Basel, Switzerland) · 2026Article
- Combined Thermal and Colorimetric Analysis as a Tool for Detecting Counterfeit ViagraPharmaceuticals (Basel, Switzerland) · 2025Article
- Royal honey packs and erectile dysfunction: viral trend or psychosocial gateway to care?International journal of impotence research · 2025Review
- Detection and quantification of Sildenafil and Tadalafil in dietary supplements marketed as natural sexual enhancers in Bosnia and Herzegovina.Central European journal of public health · 2025Article
- Benchtop NMR Coupled with Chemometrics: A Workflow for Unveiling Hidden Drug Ingredients in Honey-Based Supplements.Molecules (Basel, Switzerland) · 2024Article
- Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reports an important investigation and quantification of adulteration of sexual enhancement supplements with prescription medicines available in United Arab Emirates (UAE): tadalafil, sildenafil and vardenafil. A total of 158 sexual enhancement supplements were collected and analyzed in the current study. The samples were screened using REVERSE-phase liquid chromatography tandem high-resolution mass spectrometry/mass spectrometry (RP-HPLC-MS/MS). Of all sexual enhancements, 12.7% (95% CI: 7.4-18) contained undeclared sildenafil, 3.8% (95% CI: 0.78-6.81) contained undeclared tadalafil and 1.9% (95% CI: 0.25-4.05) contained undeclared vardenafil. Of all sexual enhancement supplements, 13.9% (95% CI: 8.5-19.4) contained significant concentrations of sildenafil, tadalafil or vardenafil. While the study found relatively low levels of undeclared pharmaceutical ingredients in the sexual enhancement dietary supplements available on the UAE market, it is likely that patients with ED tend to consume multiple such supplements daily, thereby exposing themselves to highly elevated cumulative levels.
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Registered trials
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