Evidence map›Paper›PMID 36235258›Full record

ArticleMolecules (Basel, Switzerland)2022

Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity.

Aruna Chhikara, Praveen K Roayapalley, Hiroshi Sakagami, Shigeru Amano, Keitaro Satoh, Yoshihiro Uesawa, Umashankar Das, Swagatika Das, Edgar A Borrego, Cristina D Guerena and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aruna ChhikaraDepartment of Chemistry, Dyal Singh College, University of Delhi, New Delhi 110003, India.
Praveen K RoayapalleyDrug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0003-3712-5790
Hiroshi SakagamiSchool of Dentistry, Meikai University, Sakado 350-0283, Japan.ORCID 0000-0001-8001-2121
Shigeru AmanoSchool of Dentistry, Meikai University, Sakado 350-0283, Japan.
Keitaro SatohSchool of Dentistry, Meikai University, Sakado 350-0283, Japan.
Yoshihiro UesawaDepartment of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan.ORCID 0000-0002-5773-991X
Umashankar DasDrug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Swagatika DasDrug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Edgar A BorregoDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.
Cristina D GuerenaDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.
Clare R HernandezDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.
Renato J AguileraDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.ORCID 0000-0003-3765-2793
Jonathan R DimmockDrug Discovery and Development Research Cluster, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI ARSHAD M. KHAN · 2019 to 2026
$35.1M
NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

Two series of novel unsymmetrical 3,5-bis(benzylidene)-4 piperidones

Indexed as

Antineoplastic AgentsPiperidonesApoptosisCarbonCaspase 3Cell Line, TumorHumans3,5-bis(benzylidene)-4-piperidoneAntineoplastic AgentsCarbonCaspase 3Piperidones4-piperidonesapoptosisconjugated unsaturated ketonescytotoxicitymitochondrial membrane potentialreactive oxygen speciesselectivity index

Identifiers

PMID36235258
PMCPMC9572513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.