Evidence map›Paper›PMID 36235244›Full record

ArticleMolecules (Basel, Switzerland)2022

The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation.

Radwa E Mahgoub, Feda E Mohamed, Lara Alzyoud, Bassam R Ali, Juliana Ferreira, Wael M Rabeh, Shaikha S AlNeyadi, Noor Atatreh, Mohammad A Ghattas

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Radwa E MahgoubCollege of Pharmacy, Al Ain University, Abu Dhabi 64141, United Arab Emirates.
Feda E MohamedDepartment of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.ORCID 0000-0003-0110-2351
Lara AlzyoudCollege of Pharmacy, Al Ain University, Abu Dhabi 64141, United Arab Emirates.ORCID 0000-0001-9307-3644
Bassam R AliDepartment of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.ORCID 0000-0003-1306-6618
Juliana FerreiraScience Division, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.
Wael M RabehScience Division, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates.
Shaikha S AlNeyadiDepartment of Chemistry, College of Science, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.
Noor AtatrehCollege of Pharmacy, Al Ain University, Abu Dhabi 64141, United Arab Emirates.ORCID 0000-0002-2788-0875
Mohammad A GhattasCollege of Pharmacy, Al Ain University, Abu Dhabi 64141, United Arab Emirates.ORCID 0000-0002-2240-8037

Funding

Al Jalila Foundation AJF202073
6 · The paper itself

Abstract

The main protease enzyme (M

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Antiviral AgentsCatalytic DomainCoronavirus 3C ProteasesHumansLigandsMolecular Docking SimulationProtease Inhibitors3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesLigandsProtease Inhibitorsallosteric inhibitoraryl nitriledockingMproSARS-CoV-2structure-based virtual screening

Identifiers

PMID36235244
PMCPMC9572942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.